STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MctpMultiple C2 and transmembrane domain-containing protein; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. (982 aa)    
Predicted Functional Partners:
Esyt2
Extended synaptotagmin-like protein 2 (Esyt2) encodes a member of the Synaptotagmin family that localizes to the endoplasmic reticculum (ER). In axonal ER of motorneurons, it may be involved in coordinating intracellular calcium dynamics and constitutive membrane trafficking.
   
  
 0.723
CG33172
MIP10235p; RNA binding. It is involved in the biological process described with: negative regulation of cell population proliferation.
   
  
 0.699
mfr
Misfire, isoform F; Misfire (mfr) is a ferlin gene that encodes a protein involved in gamete generation.
      
 0.646
CG8910
FI02064p; Ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: endocytosis; protein ubiquitination; Notch signaling pathway.
      
 0.627
Mnt
Mnt, isoform I; Mnt (Mnt) encodes a protein that belongs to the basic-helic-loop-helix-zipper class of transcription factors, which form heterodimers with the protein encoded by Max. Mnt product acts as a repressor of transcription by recruiting a co-repressor complex to its genomic binding sites. It antagonizes cell growth promoting functions of the product encoded by Myc and its depletion produces flies with larger cells, increased weight, and decreased lifespan.
   
  
 0.583
hob
Hobbit, isoform B; It is involved in the biological process described with: positive regulation of intracellular transport.
      
 0.530
CG3262
Uncharacterized protein, isoform D; 4 iron, 4 sulfur cluster binding; ATP binding. It is involved in the biological process described with: mitochondrial respiratory chain complex I assembly; iron-sulfur cluster assembly.
      
 0.526
CG13868
Uncharacterized protein, isoform A.
      
 0.523
Glo1
Glyoxalase 1; Lactoylglutathione lyase activity; metal ion binding. It is involved in the biological process described with: regulation of insulin receptor signaling pathway.
      
 0.507
Syt14
Synaptotagmin 14, isoform D.
   
 
 0.498
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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