STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tsp96FTetraspanin. (284 aa)    
Predicted Functional Partners:
CG13272
FI02253p.
      
 0.836
CG5948
Uncharacterized protein, isoform A; Superoxide dismutase activity; copper ion binding. It is involved in the biological process described with: removal of superoxide radicals.
      
 0.671
TSG101
Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles.
      
 0.650
ringer
Tubulin polymerization-promoting protein homolog; Regulator of microtubule required for axonal extension during embryonic development. Promotes microtubule bundling and polymerization. Together with futsch, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules ; Belongs to the TPPP family.
      
 0.629
Tsp74F
Tetraspanin 74F (Tsp74F) encodes encodes a tetraspanin, which spans the membrane four times. When the products of both Tsp74F and Tsp66E are removed, this results in defects in actin polarization, endocytosis, and distribution of the integrin subunit encoded by if during oogenesis.
  
 
 
0.597
Tsp26A
Tetraspanin 26A (Tsp26A) encodes a member of the tetraspanin superfamily. With two other tetraspanins, encoded by Tsp3A and Tsp86D, it regulates the trafficking of the product of kuz and consequently Notch signaling and several Notch-dependent developmental processes.
    
 
0.542
hmw
Protein hemingway; Involved in assembly and/or maintenance of motile cilia. Required during spermatogenesis for axoneme elongation. Necessary for optimal function of the chordotonal (hearing) organs.
    
 
 0.529
Lcp1
Larval cuticle protein 1; Component of the larval cuticle.
      
 0.523
sick
Sickie (sick) encodes a cytoskeletal protein that positively regulates F-actin-mediated axonal growth by relaying the non-canonical RacGTPase-Slingshot-Cofilin pathway. It also mediates immune deficiency signaling pathway, which activates the product of Rel; Belongs to the Nav/unc-53 family.
   
  
 0.497
Cnx99A
Calnexin 99A (Cnx99A) encodes an endoplasmic reticulum chaperone that colocalizes and genetically interacts with the sodium channel subunit encoded by para.
      
 0.495
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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