node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BicD | CG9279 | FBpp0303259 | FBpp0074744 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | GH09006p; Microtubule plus-end binding. It is involved in the biological process described with: establishment of mitotic spindle orientation; cytoplasmic microtubule organization; nuclear migration. | 0.905 |
BicD | DCTN1-p150 | FBpp0303259 | FBpp0075498 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. | 0.804 |
BicD | DCTN2-p50 | FBpp0303259 | FBpp0087722 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | Dynactin 2, p50 subunit (DCTN2-p50) encodes a subunit of the dynactin complex. Together with other members of the dynactin complex, the product of DCTN2-p50 is critical for most functions of the minus end-directed microtubule motor cytoplasmic dynein-1, including oocyte polarity, mRNA localization, centrosome localizations, spindle organization, endocytosis and axonal transport. | 0.983 |
BicD | Dhc64C | FBpp0303259 | FBpp0304991 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis. | 0.834 |
BicD | Dlic | FBpp0303259 | FBpp0073299 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | 0.980 |
BicD | Lis-1 | FBpp0303259 | FBpp0089100 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] | 0.863 |
BicD | Rab6 | FBpp0303259 | FBpp0312096 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | Ras-related protein Rab6; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regula [...] | 0.984 |
BicD | egl | FBpp0303259 | FBpp0113078 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | Egalitarian, isoform B; Egalitarian (egl) encodes an RNA binding protein that links specific mRNAs to the minus end-directed microtubule motor, cytoplasmic dynein-1. | 0.997 |
BicD | orb | FBpp0303259 | FBpp0306565 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | Oo18 RNA-binding protein (orb) encodes a RNA-binding protein required for the formation of the egg chamber and establishment of polarity during oogenesis. It is involved in mRNA polyadenylation and the regulation of osk mRNA translation. | 0.815 |
BicD | osk | FBpp0303259 | FBpp0081435 | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | Maternal effect protein oskar; Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole. | 0.904 |
CG9279 | BicD | FBpp0074744 | FBpp0303259 | GH09006p; Microtubule plus-end binding. It is involved in the biological process described with: establishment of mitotic spindle orientation; cytoplasmic microtubule organization; nuclear migration. | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | 0.905 |
CG9279 | DCTN2-p50 | FBpp0074744 | FBpp0087722 | GH09006p; Microtubule plus-end binding. It is involved in the biological process described with: establishment of mitotic spindle orientation; cytoplasmic microtubule organization; nuclear migration. | Dynactin 2, p50 subunit (DCTN2-p50) encodes a subunit of the dynactin complex. Together with other members of the dynactin complex, the product of DCTN2-p50 is critical for most functions of the minus end-directed microtubule motor cytoplasmic dynein-1, including oocyte polarity, mRNA localization, centrosome localizations, spindle organization, endocytosis and axonal transport. | 0.976 |
CG9279 | Dhc64C | FBpp0074744 | FBpp0304991 | GH09006p; Microtubule plus-end binding. It is involved in the biological process described with: establishment of mitotic spindle orientation; cytoplasmic microtubule organization; nuclear migration. | Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis. | 0.661 |
CG9279 | Dlic | FBpp0074744 | FBpp0073299 | GH09006p; Microtubule plus-end binding. It is involved in the biological process described with: establishment of mitotic spindle orientation; cytoplasmic microtubule organization; nuclear migration. | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | 0.912 |
CG9279 | Lis-1 | FBpp0074744 | FBpp0089100 | GH09006p; Microtubule plus-end binding. It is involved in the biological process described with: establishment of mitotic spindle orientation; cytoplasmic microtubule organization; nuclear migration. | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] | 0.646 |
CG9279 | Rab6 | FBpp0074744 | FBpp0312096 | GH09006p; Microtubule plus-end binding. It is involved in the biological process described with: establishment of mitotic spindle orientation; cytoplasmic microtubule organization; nuclear migration. | Ras-related protein Rab6; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regula [...] | 0.571 |
DCTN1-p150 | BicD | FBpp0075498 | FBpp0303259 | Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. | 0.804 |
DCTN1-p150 | DCTN2-p50 | FBpp0075498 | FBpp0087722 | Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. | Dynactin 2, p50 subunit (DCTN2-p50) encodes a subunit of the dynactin complex. Together with other members of the dynactin complex, the product of DCTN2-p50 is critical for most functions of the minus end-directed microtubule motor cytoplasmic dynein-1, including oocyte polarity, mRNA localization, centrosome localizations, spindle organization, endocytosis and axonal transport. | 0.994 |
DCTN1-p150 | Dhc64C | FBpp0075498 | FBpp0304991 | Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. | Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis. | 0.889 |
DCTN1-p150 | Dlic | FBpp0075498 | FBpp0073299 | Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | 0.816 |