STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HmxHomeobox protein Hmx; Transcription factor involved in specification of neuronal cell types; Belongs to the HMX homeobox family. (718 aa)    
Predicted Functional Partners:
ADPS
Alkyldihydroxyacetonephosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
      
 0.602
Awh
LIM/homeobox protein Awh; Probable transcription factor. Required for the establishment of a subset of imaginal tissues: the abdominal histoblasts and the salivary gland imaginal rings.
   
  
 0.575
Tusp
Tusp, isoform F; Tusp (Tusp) encodes a protein involved in SNARE complex assembly; Belongs to the TUB family.
      
 0.523
dac
Dachshund, isoform B; Dachshund (dac) encodes a transcriptional cofactor that physically interacts with several other retinal determination proteins, including those encoded by eya and so, and regulates eye, leg, gonad, and brain development.
    
 
 0.510
DCAF12
DDB1 and CUL4 associated factor 12, isoform A; It is involved in the biological process described with: regulation of programmed cell death; salivary gland cell autophagic cell death.
      
 0.493
dpr15
Defective proboscis extension response 15, isoform A; It is involved in the biological process described with: sensory perception of chemical stimulus; synapse organization.
      
 0.489
schlank
Schlank, isoform A; Schlank (schlank) encodes a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators.
      
 0.463
I-2
Inhibitor-2, isoform B; Inhibitor-2 (I-2) encodes a protein phosphatase 1 inhibitor.
      
 0.461
Sidpn
Similar to deadpan; Protein dimerization activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of neurogenesis; anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; cell differentiation; regulation of transcription, DNA-templated.
    
 
 0.447
Rfx
Rfx, isoform H; Rfx (Rfx) encodes a transcription factor involved in the differentiation of ciliated sensory neurons.
   
  
 0.431
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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