node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Vang | dgo | FBpp0303474 | FBpp0087345 | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | 0.998 |
Vang | dsh | FBpp0303474 | FBpp0073310 | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. | 0.999 |
Vang | esn | FBpp0303474 | FBpp0302896 | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | Espinas (esn) encodes a LIM domain protein that binds to the seven-pass transmembrane cadherin encoded by stan. This stan-esn interplay elicits repulsion between dendritic branches of sensory neurons; Belongs to the prickle / espinas / testin family. | 0.999 |
Vang | fz | FBpp0303474 | FBpp0303135 | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | Frizzled; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to inv [...] | 0.999 |
Vang | fz3 | FBpp0303474 | FBpp0111841 | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.999 |
Vang | in | FBpp0303474 | FBpp0077841 | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | Inturned (in) encodes a cytoplasmic protein that functions as a downstream member of the fz-stan planar cell polarity pathway, which controls hair and bristle polarity in the adult. In directly binds with the products of fy, frtz and mwh and accumulates on the proximal side of wing cells. | 0.838 |
Vang | pk | FBpp0303474 | FBpp0088115 | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | Protein prickle; Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, [...] | 0.999 |
Vang | stan | FBpp0303474 | FBpp0303451 | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | Protocadherin-like wing polarity protein stan; Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields. During planar cell polarity, stabilizes asymmetric PCP domains together with ATP6AP2. | 0.996 |
ana2 | stan | FBpp0087766 | FBpp0303451 | Anastral spindle 2 (ana2) encodes a centriole protein that is essential for centriole assembly, promoting the assembly of the central "cartwheel" structure. It may also have an independent role in promoting asymmetric divisions in larval neuroblasts. | Protocadherin-like wing polarity protein stan; Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields. During planar cell polarity, stabilizes asymmetric PCP domains together with ATP6AP2. | 0.839 |
dgo | Vang | FBpp0087345 | FBpp0303474 | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | 0.998 |
dgo | dsh | FBpp0087345 | FBpp0073310 | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. | 0.997 |
dgo | esn | FBpp0087345 | FBpp0302896 | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | Espinas (esn) encodes a LIM domain protein that binds to the seven-pass transmembrane cadherin encoded by stan. This stan-esn interplay elicits repulsion between dendritic branches of sensory neurons; Belongs to the prickle / espinas / testin family. | 0.983 |
dgo | fz | FBpp0087345 | FBpp0303135 | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | Frizzled; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to inv [...] | 0.996 |
dgo | fz3 | FBpp0087345 | FBpp0111841 | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.980 |
dgo | in | FBpp0087345 | FBpp0077841 | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | Inturned (in) encodes a cytoplasmic protein that functions as a downstream member of the fz-stan planar cell polarity pathway, which controls hair and bristle polarity in the adult. In directly binds with the products of fy, frtz and mwh and accumulates on the proximal side of wing cells. | 0.847 |
dgo | pk | FBpp0087345 | FBpp0088115 | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | Protein prickle; Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, [...] | 0.999 |
dgo | stan | FBpp0087345 | FBpp0303451 | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | Protocadherin-like wing polarity protein stan; Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields. During planar cell polarity, stabilizes asymmetric PCP domains together with ATP6AP2. | 0.989 |
dsh | Vang | FBpp0073310 | FBpp0303474 | Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. | 0.999 |
dsh | dgo | FBpp0073310 | FBpp0087345 | Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. | Diego, isoform A; Diego (dgo) encodes an ankyrin-repeat protein involved in planar cell polarity. | 0.997 |
dsh | esn | FBpp0073310 | FBpp0302896 | Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. | Espinas (esn) encodes a LIM domain protein that binds to the seven-pass transmembrane cadherin encoded by stan. This stan-esn interplay elicits repulsion between dendritic branches of sensory neurons; Belongs to the prickle / espinas / testin family. | 0.999 |