STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KuaKua, isoform A. (310 aa)    
Predicted Functional Partners:
Uev1A
Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion.
 
  
   0.929
CG14507
Calcium ion binding; phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process; lipid catabolic process.
     
 0.904
CG7149
GH11618p; Ethanolaminephosphotransferase activity; phosphotransferase activity, for other substituted phosphate groups. It is involved in the biological process described with: phosphatidylethanolamine biosynthetic process; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
 0.902
CG33116
FI05338p; Phosphotransferase activity, for other substituted phosphate groups; ethanolaminephosphotransferase activity. It is involved in the biological process described with: phosphatidylethanolamine biosynthetic process; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
 0.902
Pld
Phospholipase; Phosphatidylinositol binding; phospholipase D activity.
     
 0.901
CG3009
RH14732p; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process.
     
  0.900
iPLA2-VIA
Calcium-independent phospholipase A2 VIA (iPLA2-VIA) encodes a protein that localizes to cytosol and mitochondria involved in repairing oxidized mitochondrial lipids, such as cardiolipin, and thus preventing cytochrome c release. It is partially responsible for cardiolipin depletion and monolysocardiolipin accumulation in Taz-deficient flies, which is a model of Barth syndrome.
     
  0.900
sPLA2
Secretory phospholipase A2, isoform A; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process.
     
  0.900
CG30503
RH50933p; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process.
     
  0.900
GXIVsPLA2
Group XIV secreted phospholipase A2; Calcium ion binding; phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process; lipid catabolic process.
   
 
  0.900
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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