node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arr2 | CG31140 | FBpp0076326 | FBpp0303397 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Nucleic acid binding; NAD+ kinase activity; diacylglycerol kinase activity. | 0.410 |
Arr2 | Dgkepsilon | FBpp0076326 | FBpp0086966 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Diacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid. | 0.409 |
Arr2 | PIP5K59B | FBpp0076326 | FBpp0293461 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Phosphatidylinositol 4-phosphate 5-kinase at 59B, isoform E. | 0.430 |
Arr2 | ninaE | FBpp0076326 | FBpp0083266 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. | 0.999 |
Arr2 | norpA | FBpp0076326 | FBpp0290690 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.941 |
Arr2 | rdgA | FBpp0076326 | FBpp0305778 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Retinal degeneration A (rdgA) encodes a diacylglycerol kinase that mediates the conversion of diacylglycerol to phosphatidic acid. It contributes to phospholipase C based signalling reactions, controlling ion channel activity and protein transport. | 0.582 |
Arr2 | rdgB | FBpp0076326 | FBpp0304106 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Retinal degeneration B (rdgB) encodes a member of the Class IIA Phosphatidylinositol transfer protein (PITP) family. It supports multiple biochemical functions involving lipid transfer during G-protein coupled phospholipase C activation. | 0.686 |
Arr2 | rdgC | FBpp0076326 | FBpp0309721 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Retinal degeneration C (rdgC) encodes a serine/threonine phosphatase that binds Ca2+/calmodulin and contains 2 Ca2+-binding EF-hand motifs. It promotes the dephosphorylation of the product of ninaE, which prevents its internalization. It also promotes the dephosphorylation of the product of trp at specific site affecting the frequency response to modulated light. | 0.842 |
CG31140 | Arr2 | FBpp0303397 | FBpp0076326 | Nucleic acid binding; NAD+ kinase activity; diacylglycerol kinase activity. | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 0.410 |
CG31140 | PIP5K59B | FBpp0303397 | FBpp0293461 | Nucleic acid binding; NAD+ kinase activity; diacylglycerol kinase activity. | Phosphatidylinositol 4-phosphate 5-kinase at 59B, isoform E. | 0.423 |
CG31140 | laza | FBpp0303397 | FBpp0078160 | Nucleic acid binding; NAD+ kinase activity; diacylglycerol kinase activity. | HL01743p; Lazaro (laza) encodes a protein involved in phototransduction, response to light intensity and thermotaxis. | 0.650 |
CG31140 | norpA | FBpp0303397 | FBpp0290690 | Nucleic acid binding; NAD+ kinase activity; diacylglycerol kinase activity. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.970 |
CG31140 | rdgA | FBpp0303397 | FBpp0305778 | Nucleic acid binding; NAD+ kinase activity; diacylglycerol kinase activity. | Retinal degeneration A (rdgA) encodes a diacylglycerol kinase that mediates the conversion of diacylglycerol to phosphatidic acid. It contributes to phospholipase C based signalling reactions, controlling ion channel activity and protein transport. | 0.502 |
CG31140 | rdgB | FBpp0303397 | FBpp0304106 | Nucleic acid binding; NAD+ kinase activity; diacylglycerol kinase activity. | Retinal degeneration B (rdgB) encodes a member of the Class IIA Phosphatidylinositol transfer protein (PITP) family. It supports multiple biochemical functions involving lipid transfer during G-protein coupled phospholipase C activation. | 0.798 |
Dgkepsilon | Arr2 | FBpp0086966 | FBpp0076326 | Diacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid. | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 0.409 |
Dgkepsilon | PIP5K59B | FBpp0086966 | FBpp0293461 | Diacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid. | Phosphatidylinositol 4-phosphate 5-kinase at 59B, isoform E. | 0.441 |
Dgkepsilon | laza | FBpp0086966 | FBpp0078160 | Diacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid. | HL01743p; Lazaro (laza) encodes a protein involved in phototransduction, response to light intensity and thermotaxis. | 0.677 |
Dgkepsilon | norpA | FBpp0086966 | FBpp0290690 | Diacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.970 |
Dgkepsilon | rdgB | FBpp0086966 | FBpp0304106 | Diacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid. | Retinal degeneration B (rdgB) encodes a member of the Class IIA Phosphatidylinositol transfer protein (PITP) family. It supports multiple biochemical functions involving lipid transfer during G-protein coupled phospholipase C activation. | 0.677 |
PIP5K59B | Arr2 | FBpp0293461 | FBpp0076326 | Phosphatidylinositol 4-phosphate 5-kinase at 59B, isoform E. | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 0.430 |