node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Balat | CarT | FBpp0086928 | FBpp0080925 | Beta-alanine transporter; Beta-alanine transporter required for the uptake of beta- alanine by the glia. Required for the recycling process of the neurotransmitter histamine in photoreceptor neurons of the compound eye and therefore for photoreceptor synaptic transmission. Following histamine release from photoreceptors and its uptake by glia, histamine is conjugated to beta-alanine by e/Ebony to form the inactive metabolite, carcinine. | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.498 |
Balat | Hdc | FBpp0086928 | FBpp0311591 | Beta-alanine transporter; Beta-alanine transporter required for the uptake of beta- alanine by the glia. Required for the recycling process of the neurotransmitter histamine in photoreceptor neurons of the compound eye and therefore for photoreceptor synaptic transmission. Following histamine release from photoreceptors and its uptake by glia, histamine is conjugated to beta-alanine by e/Ebony to form the inactive metabolite, carcinine. | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | 0.627 |
Balat | e | FBpp0086928 | FBpp0083505 | Beta-alanine transporter; Beta-alanine transporter required for the uptake of beta- alanine by the glia. Required for the recycling process of the neurotransmitter histamine in photoreceptor neurons of the compound eye and therefore for photoreceptor synaptic transmission. Following histamine release from photoreceptors and its uptake by glia, histamine is conjugated to beta-alanine by e/Ebony to form the inactive metabolite, carcinine. | LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. | 0.416 |
CarT | Balat | FBpp0080925 | FBpp0086928 | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Beta-alanine transporter; Beta-alanine transporter required for the uptake of beta- alanine by the glia. Required for the recycling process of the neurotransmitter histamine in photoreceptor neurons of the compound eye and therefore for photoreceptor synaptic transmission. Following histamine release from photoreceptors and its uptake by glia, histamine is conjugated to beta-alanine by e/Ebony to form the inactive metabolite, carcinine. | 0.498 |
CarT | Hdc | FBpp0080925 | FBpp0311591 | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | 0.837 |
CarT | e | FBpp0080925 | FBpp0083505 | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. | 0.839 |
CarT | lovit | FBpp0080925 | FBpp0312363 | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Uncharacterized protein; Sucrose:proton symporter activity. | 0.605 |
Cndp2 | Hdc | FBpp0085374 | FBpp0311591 | RE11562p; Metallopeptidase activity; dipeptidase activity; peptidase activity. It is involved in the biological process described with: proteolysis. | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | 0.921 |
Hdc | Balat | FBpp0311591 | FBpp0086928 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Beta-alanine transporter; Beta-alanine transporter required for the uptake of beta- alanine by the glia. Required for the recycling process of the neurotransmitter histamine in photoreceptor neurons of the compound eye and therefore for photoreceptor synaptic transmission. Following histamine release from photoreceptors and its uptake by glia, histamine is conjugated to beta-alanine by e/Ebony to form the inactive metabolite, carcinine. | 0.627 |
Hdc | CarT | FBpp0311591 | FBpp0080925 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.837 |
Hdc | Cndp2 | FBpp0311591 | FBpp0085374 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | RE11562p; Metallopeptidase activity; dipeptidase activity; peptidase activity. It is involved in the biological process described with: proteolysis. | 0.921 |
Hdc | HisCl1 | FBpp0311591 | FBpp0081946 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Histamine-gated chloride channel subunit 1 (HisCl1) encodes an ion transmembrane transport complex subunit that contributes to thermotaxis and chloride transport; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.844 |
Hdc | Trh | FBpp0311591 | FBpp0072534 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Tryptophan hydroxylase (Trh) encodes an enzyme that functions as the first and rate-limiting step in the synthesis of serotonin. | 0.626 |
Hdc | e | FBpp0311591 | FBpp0083505 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. | 0.701 |
Hdc | lovit | FBpp0311591 | FBpp0312363 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Uncharacterized protein; Sucrose:proton symporter activity. | 0.740 |
Hdc | mRpL21 | FBpp0311591 | FBpp0312166 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Mitochondrial ribosomal protein L21, isoform A; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation. | 0.680 |
Hdc | mRpL3 | FBpp0311591 | FBpp0073906 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Mitochondrial ribosomal protein L3; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation. | 0.662 |
Hdc | ort | FBpp0311591 | FBpp0083198 | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | Ora transientless (ort) encodes an ionotropic histamine-gated chloride channel required for vision. It is essential in the first-order interneurons to receive histaminergic inputs from the photoreceptors. In the central brain the product of ort modulates preference and tolerance for high and low temperature; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.812 |
HisCl1 | Hdc | FBpp0081946 | FBpp0311591 | Histamine-gated chloride channel subunit 1 (HisCl1) encodes an ion transmembrane transport complex subunit that contributes to thermotaxis and chloride transport; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. | 0.844 |
HisCl1 | ort | FBpp0081946 | FBpp0083198 | Histamine-gated chloride channel subunit 1 (HisCl1) encodes an ion transmembrane transport complex subunit that contributes to thermotaxis and chloride transport; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | Ora transientless (ort) encodes an ionotropic histamine-gated chloride channel required for vision. It is essential in the first-order interneurons to receive histaminergic inputs from the photoreceptors. In the central brain the product of ort modulates preference and tolerance for high and low temperature; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.945 |