STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gbs-76AGlycogen-binding subunit 76A; Protein phosphatase 1 binding; glycogen binding. It is involved in the biological process described with: regulation of glycogen biosynthetic process. (681 aa)    
Predicted Functional Partners:
Pp1-13C
Serine/threonine-protein phosphatase alpha-3 isoform; Protein phosphatase 1 at 13C (Pp1-13C) encodes a phosphatase involved in hedgehog signaling regulation and sperm competition.
    
 0.829
Pp1alpha-96A
Serine/threonine-protein phosphatase alpha-1 isoform; Protein phosphatase 1alpha at 96A (Pp1alpha-96A) encodes a phosphatase involved in the regulation of Hedgehog and Wnt signaling pathways.
    
 0.820
Pp1-87B
Serine/threonine-protein phosphatase alpha-2 isoform; Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase; Belongs to the PPP phosphatase family. PP-1 subfamily.
    
 0.819
Gbs-70E
Protein phosphatase 1 regulatory subunit; Glycogen binding subunit 70E (Gbs-70E) is one of the glycogen binding subunits of protein phosphatase 1 (Pp1) that interacts with all of the known Pp1 catalytic subunits (encoded by Pp1-87B, flw, Pp1alpha-96A, and Pp1-13C). The product of Gbs-70E is involved in the regulation of glycogen metabolism, and plays a role in the egg development.
  
0.800
GlyS
Glycogen synthase (GlyS) encodes a glycosyltransferase that catalyzes linkage of glucose monomers into glycogen. Regulation of the product of GlyS activity by glucose 6-phosphate and phosphorylation helps control cellular glycogen levels.
   
 
 0.770
PpN58A
Protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; Belongs to the PPP phosphatase family.
    
 0.647
PpD5
Protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; Belongs to the PPP phosphatase family.
    
 0.646
flw
Serine/threonine-protein phosphatase beta isoform; Required for cell adhesion in non-muscle tissues and in maintenance of muscle attachment. Vital for larval development. Belongs to the PPP phosphatase family. PP-1 subfamily.
    
 
 0.622
Ttd14
TRPL translocation defect protein 14; GTP-binding protein which is required for the light-dependent internalization of the TRPL ion channel from the rhabdomere on the apical surface of photoreceptor cells to the cell body and for the recycling of TRPL back to the rhabdomere in the dark. Binds to 3- phosphoinositide (PtdIns(3)P) and phosphatic acid and so may interact with membranes, particularly the early endosome membrane where PtdIns(3)P is predominantly localized. Plays a role in preventing photoreceptor degeneration.
   
  
 0.606
beat-Vc
Beaten path Vc; It is involved in the biological process described with: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; motor neuron axon guidance.
      
 0.603
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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