node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG1924 | CG6766 | FBpp0073467 | FBpp0079892 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | 0.454 |
CG1924 | Calr | FBpp0073467 | FBpp0306685 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). | 0.877 |
CG1924 | Cnx14D | FBpp0073467 | FBpp0074074 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | Calnexin 14D; Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; protein folding. | 0.915 |
CG1924 | Der-2 | FBpp0073467 | FBpp0082758 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | 0.684 |
CG1924 | Edem1 | FBpp0073467 | FBpp0304832 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | alpha-1,2-Mannosidase; ER degradation enhancer, mannosidase alpha-like 1 (Edem1) encodes a lectin in the endoplasmic reticulum (ER) lumen that helps to recognize specific misfolded glycoproteins in this cellular compartment for retro-translation to the cytoplasm and ubiquitin-mediated degradation. This process is referred to as "ER-Associated Degradation"; Belongs to the glycosyl hydrolase 47 family. | 0.820 |
CG1924 | Hsc70-3 | FBpp0073467 | FBpp0073447 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.919 |
CG1924 | Uggt | FBpp0073467 | FBpp0074831 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | UDP-glucose-glycoprotein glucosyltransferase (Uggt) encodes an enzyme that recognizes glycoproteins with folding defects and adds glucose to N-glycans near the misfolded part of the protein. Uggt product is a component of the calnexin cycle and promotes protein folding in the endoplasmic reticulum along with the protein encoded by Cnx99A and Calr; Belongs to the glycosyltransferase 8 family. | 0.948 |
CG1924 | Xbp1 | FBpp0073467 | FBpp0301746 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | X box binding protein-1 (Xbp1) encodes a transcription factor that mediates the unfolded protein response. Xbp1 mRNA undergoes splicing after being cleaved by the product of Ire1, inducing the expression of ER quality control transcripts. Xbp1 mutants fail to develop beyond the 2nd instar larval stage, indicative of a requirement to resolve inherent ER stress during normal development. | 0.788 |
CG6766 | CG1924 | FBpp0079892 | FBpp0073467 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | 0.454 |
CG6766 | Calr | FBpp0079892 | FBpp0306685 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). | 0.525 |
CG6766 | Cnx14D | FBpp0079892 | FBpp0074074 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Calnexin 14D; Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; protein folding. | 0.453 |
CG6766 | Der-2 | FBpp0079892 | FBpp0082758 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | 0.996 |
CG6766 | Edem1 | FBpp0079892 | FBpp0304832 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | alpha-1,2-Mannosidase; ER degradation enhancer, mannosidase alpha-like 1 (Edem1) encodes a lectin in the endoplasmic reticulum (ER) lumen that helps to recognize specific misfolded glycoproteins in this cellular compartment for retro-translation to the cytoplasm and ubiquitin-mediated degradation. This process is referred to as "ER-Associated Degradation"; Belongs to the glycosyl hydrolase 47 family. | 0.799 |
CG6766 | Edem2 | FBpp0079892 | FBpp0080019 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | alpha-1,2-Mannosidase; ER degradation enhancer, mannosidase alpha-like 2 (Edem2) encodes a lectin involved in the degradation of proteins during endoplasmic reticulum (ER) stress, which is generated by the presence of unfolded proteins in the ER; Belongs to the glycosyl hydrolase 47 family. | 0.483 |
CG6766 | Hsc70-3 | FBpp0079892 | FBpp0073447 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.873 |
CG6766 | Uggt | FBpp0079892 | FBpp0074831 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | UDP-glucose-glycoprotein glucosyltransferase (Uggt) encodes an enzyme that recognizes glycoproteins with folding defects and adds glucose to N-glycans near the misfolded part of the protein. Uggt product is a component of the calnexin cycle and promotes protein folding in the endoplasmic reticulum along with the protein encoded by Cnx99A and Calr; Belongs to the glycosyltransferase 8 family. | 0.682 |
Calr | CG1924 | FBpp0306685 | FBpp0073467 | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. | 0.877 |
Calr | CG6766 | FBpp0306685 | FBpp0079892 | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | 0.525 |
Calr | Cnx14D | FBpp0306685 | FBpp0074074 | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). | Calnexin 14D; Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; protein folding. | 0.878 |
Calr | Der-2 | FBpp0306685 | FBpp0082758 | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | 0.536 |