STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp28c1Probable cytochrome P450 28c1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (505 aa)    
Predicted Functional Partners:
Fdx2
Adrenodoxin-like protein 2, mitochondrial; Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the adrenodoxin/putidaredoxin family.
  
 
 0.701
spo
Spook (spo) encodes a cytochrome P450 involved in ecdysteroid biosynthesis in the embryo. spo mutants fail to undergo head involution, dorsal closure or to secrete cuticle.
  
 
 0.524
Cyp301a1
Probable cytochrome P450 301a1, mitochondrial; Cyp301a1 (Cyp301a1) encodes a member of the cytochrome P450 family, which have both mitochondrial and cytosolic roles in the detoxification of compounds.
  
 
   0.497
Cyp303a1
Probable cytochrome P450 303a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.481
Cyp12e1
Probable cytochrome P450 12e1, mitochondrial; Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.
  
 
 
0.462
nvd
Rieske-domain protein Neverland; Neverland (nvd) encodes an evolutionarily conserved oxygenase-like protein that is required for the biosynthesis pathway of ecdysone. It converts cholesterol to 7-dehydrocholesterol.
  
  
 0.436
CG33557
BHLH domain-containing protein; RNA polymerase II regulatory region sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II.
    
 
 0.432
CG9541
Uncharacterized protein, isoform D; Nucleoside diphosphate kinase activity; ATP binding. It is involved in the biological process described with: nucleoside diphosphate phosphorylation; purine nucleotide metabolic process; nucleoside triphosphate biosynthetic process.
      
 0.430
CG30471
MIP31237p; Transferase activity, transferring acyl groups other than amino-acyl groups.
      
 0.428
sro
Shroud (sro) encodes a short-chain dehydrogenase/reductase that is essential for ecdysone biosynthesis. It is hypothesized to work in the conversion of 7-dehydrocholesterol to 5beta-ketodiol; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.401
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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