STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fs(1)hHomeotic protein female sterile; Required maternally for proper expression of other homeotic genes involved in pattern formation, such as Ubx. (2046 aa)    
Predicted Functional Partners:
Cp190
Centrosome-associated zinc finger protein CP190; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the [...]
   
 
 0.777
Taf7
Transcription initiation factor TFIID subunit 7; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
    
 
 0.773
BEAF-32
Boundary element-associated factor of 32kD (BEAF-32) encodes a DNA-binding protein with binding sites near transcription start sites. Its roles include chromatin domain insulator function, gene regulation and genome organization.
   
 
 0.754
mod(mdg4)
Modifier of mdg4; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independe [...]
   
 
 0.725
vtd
Rad21 mitotic cohesin; Verthandi (vtd) encodes a subunit of the cohesin complex, which encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair.
    
 
 0.705
su(Hw)
Protein suppressor of hairy wing; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fibe [...]
   
 
 0.691
Dref
DNA replication-related element factor (Dref) encodes a BED finger-type transcription factor that binds to the DRE sequence (TATCGATA). The Dref product is involved in tumor suppressor, TOR, JNK and EGFR signalling pathways. It also plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance.
   
 
 0.681
l(3)mbt
Lethal (3) malignant brain tumor (l(3)mbt) encodes a tumor suppressor protein regulating proliferation in the brain, particularly the optic lobes. The proposed functions of the product of l(3)mbt include histone compaction, establishment of chromatin insulators, regulation of the Hippo pathway and repression of the germ line program in somatic cells.
   
 
 0.670
CG7099
B-block_TFIIIC domain-containing protein; It is involved in the biological process described with: transcription initiation from RNA polymerase III promoter; 5S class rRNA transcription by RNA polymerase III.
    
 
 0.660
Br140
Bromodomain-containing protein, 140kD (Br140) encodes a histone acetyltransferase that is a component of the Enok complex, which interacts with the product of elg1 via Br140 to promote the G1/S transition via proliferating cell nuclear antigen (PCNA) unloading.
   
 
0.658
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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