node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hayan | PPO1 | FBpp0111913 | FBpp0291497 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | 0.756 |
Hayan | PPO2 | FBpp0111913 | FBpp0087744 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | 0.669 |
Hayan | Sp7 | FBpp0111913 | FBpp0308322 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Serine protease 7; Serine protease which, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding. May function in diverse Hayan-dependent PPO1- activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea. Important for the innate immune response to fungi. Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway. | 0.428 |
Hayan | Spn27A | FBpp0111913 | FBpp0305543 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Serine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...] | 0.727 |
Hayan | Spn28Dc | FBpp0111913 | FBpp0079171 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...] | 0.619 |
Hayan | Spn77Ba | FBpp0111913 | FBpp0311802 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Serine protease inhibitor 77Ba; Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection. Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade ; Belongs to the serpin family. | 0.475 |
PPO1 | Hayan | FBpp0291497 | FBpp0111913 | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | 0.756 |
PPO1 | PPO2 | FBpp0291497 | FBpp0087744 | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | 0.999 |
PPO1 | Sp7 | FBpp0291497 | FBpp0308322 | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | Serine protease 7; Serine protease which, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding. May function in diverse Hayan-dependent PPO1- activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea. Important for the innate immune response to fungi. Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway. | 0.628 |
PPO1 | Spn27A | FBpp0291497 | FBpp0305543 | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | Serine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...] | 0.861 |
PPO1 | Spn28Dc | FBpp0291497 | FBpp0079171 | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...] | 0.461 |
PPO1 | Spn77Ba | FBpp0291497 | FBpp0311802 | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | Serine protease inhibitor 77Ba; Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection. Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade ; Belongs to the serpin family. | 0.422 |
PPO1 | spz | FBpp0291497 | FBpp0084507 | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | Protein spaetzle C-106; Spatzle (spz) encodes a secreted protein which, after cleavage by an extracellular serine protease (encoded by ea or SPE), can induce the dimerization of the product of Tl, and the subsequent activation of the Toll pathway. It contributes to function of the Toll signaling cascade, which plays a key role in various developmental and immune processes, notably embryonic dorso-ventral patterning and regulation of antimicrobial peptides. | 0.443 |
PPO2 | Hayan | FBpp0087744 | FBpp0111913 | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | 0.669 |
PPO2 | PPO1 | FBpp0087744 | FBpp0291497 | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | 0.999 |
PPO2 | Sp7 | FBpp0087744 | FBpp0308322 | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | Serine protease 7; Serine protease which, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding. May function in diverse Hayan-dependent PPO1- activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea. Important for the innate immune response to fungi. Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway. | 0.497 |
PPO2 | Spn27A | FBpp0087744 | FBpp0305543 | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | Serine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...] | 0.724 |
Sp7 | Hayan | FBpp0308322 | FBpp0111913 | Serine protease 7; Serine protease which, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding. May function in diverse Hayan-dependent PPO1- activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea. Important for the innate immune response to fungi. Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway. | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | 0.428 |
Sp7 | PPO1 | FBpp0308322 | FBpp0291497 | Serine protease 7; Serine protease which, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding. May function in diverse Hayan-dependent PPO1- activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea. Important for the innate immune response to fungi. Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway. | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | 0.628 |
Sp7 | PPO2 | FBpp0308322 | FBpp0087744 | Serine protease 7; Serine protease which, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding. May function in diverse Hayan-dependent PPO1- activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea. Important for the innate immune response to fungi. Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway. | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | 0.497 |