STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nrv3Nervana 3 (nrv3) encodes one of three beta subunits of the sodium-potassium pump (ATPalpha). nrv3 is expressed in the nervous system, including subsets of the CNS and Johnston's organ neurons, and is required for hearing. (313 aa)    
Predicted Functional Partners:
Atpalpha
Sodium/potassium-transporting ATPase subunit alpha; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
   
 0.967
JYalpha
Sodium/potassium-transporting ATPase subunit alpha; JYalpha (JYalpha) is a gene essential for male fertility as mutants produce immotile sperm.
   
 0.866
CG45062
Uncharacterized protein, isoform A; ATPase activity; nucleotide binding; calcium transmembrane transporter activity, phosphorylative mechanism; proton-exporting ATPase activity, phosphorylative mechanism. It is involved in the biological process described with: calcium ion transmembrane transport; cellular calcium ion homeostasis.
    
 0.820
CG7912
LP13633p; Secondary active sulfate transmembrane transporter activity; anion:anion antiporter activity; sulfate transmembrane transporter activity. It is involved in the biological process described with: sulfate transport; transmembrane transport.
   
  
 0.792
CG6329
GEO05126p1; GPI anchor binding. It is involved in the biological process described with: positive regulation of voltage-gated potassium channel activity; sleep; regulation of synaptic transmission, cholinergic.
  
    0.756
CG45063
Cation_ATPase_N domain-containing protein.
    
 
 0.654
Syt4
Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment.
   
    0.653
CG5404
GH25012p; Sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; anion:anion antiporter activity. It is involved in the biological process described with: transmembrane transport; sulfate transport.
   
  
 0.652
CG2991
LD08641p; Zinc ion binding; ubiquitin protein ligase activity.
   
  
 0.644
nrv1
Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
  
 
0.605
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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