STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hzgPhosphatase Herzog; Prion-like membrane-associated phosphatase. Phosphatase activity depends on amyloid-like assembly at the membrane. Might have a role in establishment of segment polarity in embryos. (352 aa)    
Predicted Functional Partners:
sds22
GH07711p; It is involved in the biological process described with: negative regulation of cell population proliferation; establishment or maintenance of polarity of larval imaginal disc epithelium; establishment or maintenance of polarity of follicular epithelium.
 
 
    0.893
TfIIFalpha
General transcription factor IIF subunit 1; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.
    
 
 0.615
Fcp1
RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.
      
 0.610
fmt
Fiery mountain, isoform D; Protein phosphatase regulator activity. It is involved in the biological process described with: regulation of phosphoprotein phosphatase activity; negative regulation of JNK cascade.
   
  
 0.563
CG8230
Dymeclin; It is involved in the biological process described with: Golgi organization; Belongs to the dymeclin family.
   
  
 0.526
orb2
Translational regulator orb2; Required in mushroom body gamma neurons for long-term memory in male courtship. Binds to mRNA 3'- UTRs. In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover. In its amyloid- like oligomeric form, acts as a translational activator. The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA. Isoform A is required for initial memory acquisition and, following subsequent late dopaminerg [...]
      
 0.522
Tim23
Translocase of inner mitochondrial membrane 23; Protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix.
    
 
 0.468
smash
Uncharacterized protein CG43427.
   
 
 0.445
stck
LIM domain-containing protein; Steamer duck (stck) encodes PINCH, an adapter protein that directly binds and forms a complex with the products of Ilk and ics. PINCH is required for integrin-dependent cell adhesion and signaling.
   
  
 0.442
EndoA
Endophilin-A; Endophilin A (EndoA) encodes an essential protein for synaptic vesicle endocytosis. It recruits or stabilizes the product of Synj (required for vesicle uncoating) to endocytic membranes.
   
  
 0.441
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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