STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG42748Uncharacterized protein, isoform K; Protein phosphatase 1 binding. It is involved in the biological process described with: cell-cell junction organization. (2190 aa)    
Predicted Functional Partners:
TwdlK
TweedleK; Structural constituent of chitin-based cuticle. It is involved in the biological process described with: chitin-based cuticle development; body morphogenesis.
      
 0.836
TwdlJ
RT03118p; Structural constituent of chitin-based cuticle. It is involved in the biological process described with: body morphogenesis; chitin-based cuticle development.
      
 0.680
TwdlL
TweedleL, isoform A; Structural constituent of chitin-based cuticle. It is involved in the biological process described with: chitin-based cuticle development; body morphogenesis.
      
 0.669
CG32006
RT11906p1; Sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: anatomical structure morphogenesis; cell differentiation; regulation of transcription by RNA polymerase II.
      
 0.601
TwdlM
RE40518p; Structural constituent of chitin-based cuticle. It is involved in the biological process described with: body morphogenesis; chitin-based cuticle development.
      
 0.533
l(3)neo38
Lethal (3) neo38, isoform L; Transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: regulation of chromatin silencing; positive regulation of transcription by RNA polymerase II.
   
  
 0.496
Cpr5C
Cuticular protein 5C; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development.
      
 0.495
DOR
Diabetes and obesity regulated (DOR) encodes a transcriptional coactivator of ecdysone receptor signaling required during metamorphosis. It is antagonized by insulin signaling via the product of foxo in the fat body and forms part of a feed-forward mechanism whereby ecdysone potentiates its own signaling. The product of DOR also regulates autophagosome formation and protein degradation via ecdysone signaling.
      
 0.493
Ccp84Aa
Cuticle protein; Structural constituent of chitin-based larval cuticle; structural constituent of cuticle. It is involved in the biological process described with: chitin-based cuticle development.
      
 0.467
CG30382
Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family.
      
 0.459
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.