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phl protein (fruit fly) - STRING interaction network
"phl" - Raf homolog serine/threonine-protein kinase phl in Drosophila melanogaster
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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phlRaf homolog serine/threonine-protein kinase phl; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, an hormone required for the initiation of metamorphosis (782 aa)    
Predicted Functional Partners:
Ras85D
Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (189 aa)
     
  0.999
Dsor1
Dual specificity mitogen-activated protein kinase kinase dSOR1; Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase (396 aa)
     
0.999
R
Ras-like protein 3; Rap1 GTPase is a small GTPase in the Ras superfamily. When GTP bound, it binds to a number of different effectors, one of which is cno. Together they regulate many morphogenetic movements from mesoderm invagination to dorsal closure, help establish apical-basal polarity during cellularization, regulate macrophage migration, help define neuroblast asymmetric division, and play a role in planar cell polarity in the imaginal discs (184 aa)
     
  0.997
14-3-3zeta
14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo- binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3- phosphate and promotes maturation of early endosomes (248 aa)
       
  0.995
Ras64B
Ras-like protein 2; May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family (192 aa)
       
  0.994
cnk
Connector enhancer of KSR protein CNK; Protein binding; enzyme binding. It is involved in the biological process described with- compound eye photoreceptor cell differentiation; positive regulation of Ras protein signal transduction; imaginal disc-derived wing vein morphogenesis; tracheal outgrowth, open tracheal system; positive regulation of ERK1 and ERK2 cascade; imaginal disc-derived wing morphogenesis; torso signaling pathway; anterior/posterior axis specification, embryo; Ras protein signal transduction; signal transduction (1557 aa)
     
  0.993
ksr
Kinase suppressor of ras, isoform A; Protein kinase activity; ATP binding; diacylglycerol binding; protein serine/threonine kinase activity. It is involved in the biological process described with- positive regulation of Ras protein signal transduction; protein phosphorylation; tracheal outgrowth, open tracheal system; positive regulation of ERK1 and ERK2 cascade; imaginal disc-derived wing morphogenesis; torso signaling pathway; anterior/posterior axis specification, embryo; Ras protein signal transduction; signal transduction (966 aa)
     
0.985
SR3-9
14-3-3epsilon is an acidic protein that preferentially heterodimerizes with other members of the family but also can homodimerize. It functions in multiple signaling pathways, most prominently in the Ras/MAPK cascade. It is involved in embryonic hatching, germ cell migration, gonad formation, wing venation and eye development; Belongs to the 14-3-3 family (262 aa)
       
  0.983
sty
Protein sprouty; Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL- branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells (589 aa)
       
  0.976
rl
Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis; Belongs to the protein kinase [...] (376 aa)
     
0.973
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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