node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ace | CG4757 | FBpp0082248 | FBpp0307203 | Acetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. | Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family. | 0.920 |
Ace | GluClalpha | FBpp0082248 | FBpp0310353 | Acetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. | Glutamate-gated chloride channel; Glutamate-gated chloride channel subunit. Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration. | 0.483 |
Ace | Rdl | FBpp0082248 | FBpp0305970 | Acetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. | Gamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior. | 0.740 |
CG4757 | Ace | FBpp0307203 | FBpp0082248 | Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family. | Acetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. | 0.920 |
CG4757 | GluClalpha | FBpp0307203 | FBpp0310353 | Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family. | Glutamate-gated chloride channel; Glutamate-gated chloride channel subunit. Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration. | 0.492 |
CG4757 | Rdl | FBpp0307203 | FBpp0305970 | Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family. | Gamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior. | 0.764 |
CG8916 | GABA-B-R1 | FBpp0290450 | FBpp0293274 | IP12579p; Extracellular ligand-gated ion channel activity; GABA-A receptor activity; chloride channel activity; neurotransmitter receptor activity; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. | 0.470 |
CG8916 | GABA-B-R2 | FBpp0290450 | FBpp0308298 | IP12579p; Extracellular ligand-gated ion channel activity; GABA-A receptor activity; chloride channel activity; neurotransmitter receptor activity; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | Metabotropic GABA-B receptor subtype 2, isoform C; G protein-coupled GABA receptor activity; protein heterodimerization activity; transmembrane signaling receptor activity. | 0.495 |
CG8916 | GABA-B-R3 | FBpp0290450 | FBpp0310350 | IP12579p; Extracellular ligand-gated ion channel activity; GABA-A receptor activity; chloride channel activity; neurotransmitter receptor activity; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | Metabotropic GABA-B receptor subtype 3 (GABA-B-R3) encodes a G-protein coupled receptor for the GABA neurotransmitter that is coupled to the Go G protein and activation of phospholipase C. Activation of the product of GABA-B-R3 can inhibit neuronal activity. It functions in the olfactory system and in the regulation of sleep and circadian rhythms. | 0.500 |
CG8916 | Grd | FBpp0290450 | FBpp0074905 | IP12579p; Extracellular ligand-gated ion channel activity; GABA-A receptor activity; chloride channel activity; neurotransmitter receptor activity; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | Gamma-aminobutyric acid receptor alpha-like; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. May combine with the ligand-gated ion channel subunit Lcch3 to form cation-selective GABA-gated ion channels. | 0.850 |
CG8916 | Rdl | FBpp0290450 | FBpp0305970 | IP12579p; Extracellular ligand-gated ion channel activity; GABA-A receptor activity; chloride channel activity; neurotransmitter receptor activity; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | Gamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior. | 0.737 |
GABA-B-R1 | CG8916 | FBpp0293274 | FBpp0290450 | Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. | IP12579p; Extracellular ligand-gated ion channel activity; GABA-A receptor activity; chloride channel activity; neurotransmitter receptor activity; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.470 |
GABA-B-R1 | GABA-B-R2 | FBpp0293274 | FBpp0308298 | Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. | Metabotropic GABA-B receptor subtype 2, isoform C; G protein-coupled GABA receptor activity; protein heterodimerization activity; transmembrane signaling receptor activity. | 0.996 |
GABA-B-R1 | GABA-B-R3 | FBpp0293274 | FBpp0310350 | Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. | Metabotropic GABA-B receptor subtype 3 (GABA-B-R3) encodes a G-protein coupled receptor for the GABA neurotransmitter that is coupled to the Go G protein and activation of phospholipase C. Activation of the product of GABA-B-R3 can inhibit neuronal activity. It functions in the olfactory system and in the regulation of sleep and circadian rhythms. | 0.991 |
GABA-B-R1 | Gad1 | FBpp0293274 | FBpp0073131 | Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. | Glutamic acid decarboxylase 1 (Gad1) encodes an essential, nervous system-specific glutamic acid decarboxylase, which is the synthetic enzyme for the major inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). It is required for a multitude of physiological functions and adult behaviors dependent on GABA, including sleep, memory, circadian rhythms and egg hatching; Belongs to the group II decarboxylase family. | 0.576 |
GABA-B-R1 | Grd | FBpp0293274 | FBpp0074905 | Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. | Gamma-aminobutyric acid receptor alpha-like; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. May combine with the ligand-gated ion channel subunit Lcch3 to form cation-selective GABA-gated ion channels. | 0.717 |
GABA-B-R1 | Rdl | FBpp0293274 | FBpp0305970 | Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. | Gamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior. | 0.810 |
GABA-B-R2 | CG8916 | FBpp0308298 | FBpp0290450 | Metabotropic GABA-B receptor subtype 2, isoform C; G protein-coupled GABA receptor activity; protein heterodimerization activity; transmembrane signaling receptor activity. | IP12579p; Extracellular ligand-gated ion channel activity; GABA-A receptor activity; chloride channel activity; neurotransmitter receptor activity; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.495 |
GABA-B-R2 | GABA-B-R1 | FBpp0308298 | FBpp0293274 | Metabotropic GABA-B receptor subtype 2, isoform C; G protein-coupled GABA receptor activity; protein heterodimerization activity; transmembrane signaling receptor activity. | Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways. | 0.996 |
GABA-B-R2 | GABA-B-R3 | FBpp0308298 | FBpp0310350 | Metabotropic GABA-B receptor subtype 2, isoform C; G protein-coupled GABA receptor activity; protein heterodimerization activity; transmembrane signaling receptor activity. | Metabotropic GABA-B receptor subtype 3 (GABA-B-R3) encodes a G-protein coupled receptor for the GABA neurotransmitter that is coupled to the Go G protein and activation of phospholipase C. Activation of the product of GABA-B-R3 can inhibit neuronal activity. It functions in the olfactory system and in the regulation of sleep and circadian rhythms. | 0.929 |