STRINGSTRING
drpr protein (fruit fly) - STRING interaction network
"drpr" - Protein draper in Drosophila melanogaster
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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drprProtein draper; Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria. Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis. Ligand- binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis. Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells. Required for the ph [...] (1042 aa)    
Predicted Functional Partners:
ced-6
PTB domain-containing adapter protein ced-6; Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth (533 aa)
       
 
  0.949
Ced-12
PH domain protein CED-12; Protein binding. It is involved in the biological process described with- phagocytosis; myoblast fusion; border follicle cell migration; actin filament organization; cell migration; central nervous system development; muscle attachment; activation of Rac GTPase activity (724 aa)
       
 
  0.854
shark
Tyrosine-protein kinase shark; Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system. Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity [...] (939 aa)
       
 
  0.793
Crk
Adapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family (271 aa)
     
 
  0.759
Or85e
Putative odorant receptor 85e; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity) (468 aa)
           
  0.749
crq
Croquemort (Crq) is a member of the scavenger receptor class B sub-family. Crq is expressed in plasmatocyte/macrophages and promotes apoptotic cell clearance. In epidermal cells it plays a role in phagosome maturation in both dendrite pruning and injury (491 aa)
     
 
  0.734
prtp
Thioredoxin domain-containing protein 5 homolog; Possesses thioredoxin activity (By similarity). Acts as a ligand for Drpr and is required for the phagocytosis of apoptotic cells. Binds to the extracellular region of Drpr and augments Drpr tyrosine phosphorylation; Belongs to the protein disulfide isomerase family (416 aa)
     
 
  0.672
mbc
Myoblast city, isoform B; Protein binding; Rac guanyl-nucleotide exchange factor activity; Belongs to the DOCK family (2008 aa)
     
 
  0.667
Stat92E
Signal-transducer and activator of transcription protein at 92E (Stat92E) is a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Stat92E roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning (761 aa)
       
 
  0.650
CG15561
Uncharacterized protein; Nucleic acid binding (357 aa)
           
  0.629
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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