STRINGSTRING
GJ11298 protein (Drosophila virilis) - STRING interaction network
"GJ11298" - Protein wntless in Drosophila virilis
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GJ11298Protein wntless; A segment polarity gene required for wingless (wg)- dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls- containing ex [...] (562 aa)    
Predicted Functional Partners:
wg
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (472 aa)
     
 
  0.927
GJ15051
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (343 aa)
     
 
  0.925
GJ22344
Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting (818 aa)
     
 
  0.907
GJ21907
Ligand for members of the frizzled family of seven transmembrane receptors (414 aa)
     
 
  0.898
GJ17616
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (548 aa)
     
 
  0.889
GJ14149
Uncharacterized protein; Phosphatidylinositol binding (167 aa)
     
 
  0.879
GJ18984
annotation not available (530 aa)
     
   
  0.852
GJ16978
annotation not available (539 aa)
           
  0.838
GJ19542
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway (182 aa)
           
  0.764
GJ17655
Uncharacterized protein; Phosphatidylinositol binding (461 aa)
     
 
  0.718
Your Current Organism:
Drosophila virilis
NCBI taxonomy Id: 7244
Other names: D. virilis, Drosophila virilis
Server load: low (12%) [HD]