STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A088A8G5EGF-like domain-containing protein. (216 aa)    
Predicted Functional Partners:
A0A088AS28
Receptor protein-tyrosine kinase.
    
 0.975
Wat
Uncharacterized protein.
      
 0.780
Egfr
Epidermal growth factor receptor; Upon binding to its ligands, transduces the signal through the ras-raf-MAPK pathway and is involved in a myriad of developmental decisions (By similarity). Involved in the determination of adult size, ovary development, and development timing, especially during queen determination of honeybee larvae. May have an important role in the prolongation of longevity in queens.
    
 0.760
A0A087ZWQ4
Uncharacterized protein.
    
 
 0.617
A0A087ZMW3
Uncharacterized protein.
    
 
 0.536
A0A087ZZR0
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.513
Lin-52
Uncharacterized protein.
    
 0.501
LOC409483
CRC domain-containing protein.
    
 0.490
Caf1
WD_REPEATS_REGION domain-containing protein.
    
 0.485
A0A088AEB7
DIRP domain-containing protein.
    
 0.462
Your Current Organism:
Apis mellifera
NCBI taxonomy Id: 7460
Other names: A. mellifera, Apis mellifica, European honey bee, Western honey bee, bee, honey bee, honeybee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.