STRINGSTRING
Mcdp protein (Apis mellifera) - STRING interaction network
"Mcdp" - Mast cell degranulating peptide in Apis mellifera
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
McdpMast cell degranulating peptide; Potent anti-inflammatory agent. At low concentrations, mediates the degranulation of mast cells thus evoking an inflammatory response. Also acts as a neurotoxin capable of blocking a class of voltage-gated potassium channels (50 aa)    
Predicted Functional Partners:
Melt
Melittin; Melittin- Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na(+)-K(+)-ATPase and the H(+)-K(+)-ATPase. It increases the permeability of cell membranes to ions, particularly Na(+) and indirectly Ca(2+), because of the Na(+)-Ca(2+)-exchange. It acts synergistically with phospholipase A2 (70 aa)
           
  0.630
LOC406146
Hyaluronidase; Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides (382 aa)
           
  0.540
LOC406145
Secapin; Nontoxic component of honeybee venom (77 aa)
           
  0.538
Pla2
Phospholipase A2; PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides; Belongs to the phospholipase A2 family. Group III subfamily (167 aa)
           
  0.507
Your Current Organism:
Apis mellifera
NCBI taxonomy Id: 7460
Other names: A. mellifera, Apis mellifera, Apis mellifica, European honey bee, Western honey bee, bee, honey bee, honeybee
Server load: low (25%) [HD]