STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE14072.1Sugar-phosphate isomerase, RpiB/LacA/LacB family; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: shi:Shel_21560 ribose-5-phosphate isomerase; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose-5-phosphate isomerase B; TIGRFAM: Ribose/galactose isomerase; Ribose 5-phosphate isomerase B; IMG reference gene:2504783808; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; sugar-phosphate isomerases, RpiB/LacA/LacB family. (147 aa)    
Predicted Functional Partners:
AEE14073.1
COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: cju:C8J_0424 ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Ribulose-phosphate 3-epimerase; IMG reference gene:2504783809; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase.
 
 
 0.990
AEE14068.1
1-deoxy-D-xylulose-5-phosphate synthase; COGs: COG3958 Transketolase C-terminal subunit; InterPro IPR005475:IPR005476; KEGG: adg:Adeg_1860 transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: 1-deoxy-D-xylulose-5-phosphate synthase; SPTR: Transketolase central region; IMG reference gene:2504783804; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
  
 
 0.952
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
    0.946
AEE14067.1
Transketolase; COGs: COG3959 Transketolase N-terminal subunit; InterPro IPR005474; KEGG: adg:Adeg_1861 transketolase domain protein; PFAM: Transketolase, N-terminal; PRIAM: Transketolase; SPTR: Transketolase domain protein; IMG reference gene:2504783803; PFAM: Transketolase, thiamine diphosphate binding domain.
  
 
 0.946
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
    
 0.924
AEE14404.1
1-deoxy-D-xylulose-5-phosphate synthase; COGs: COG3958 Transketolase C-terminal subunit; InterPro IPR005475:IPR005476; KEGG: ttm:Tthe_1907 transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: 1-deoxy-D-xylulose-5-phosphate synthase; SPTR: Transketolase, pyridine binding domain protein; IMG reference gene:2504784158; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
  
 
 0.912
AEE14403.1
Transketolase; COGs: COG3959 Transketolase N-terminal subunit; InterPro IPR005474; KEGG: adg:Adeg_1861 transketolase domain protein; PFAM: Transketolase, N-terminal; PRIAM: Transketolase; SPTR: Transketolase domain protein; IMG reference gene:2504784157; PFAM: Transketolase, thiamine diphosphate binding domain.
  
 
 0.910
AEE13881.1
1-phosphofructokinase; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR017583:IPR011611; KEGG: mtp:Mthe_0686 1-phosphofructokinase; PFAM: Carbohydrate/purine kinase; PRIAM: 1-phosphofructokinase; SPTR: 1-phosphofructokinase; TIGRFAM: 1-phosphofructokinase; IMG reference gene:2504783600; PFAM: pfkB family carbohydrate kinase; TIGRFAM: 1-phosphofructokinase; hexose kinase, 1-phosphofructokinase family.
  
  
 0.834
AEE14066.1
Phosphoribulokinase; COGs: COG0572 Uridine kinase; InterPro IPR006083; KEGG: adg:Adeg_1862 phosphoribulokinase/uridine kinase; PFAM: Phosphoribulokinase/uridine kinase; PRIAM: Phosphoribulokinase; SPTR: Phosphoribulokinase/uridine kinase; IMG reference gene:2504783802; PFAM: Phosphoribulokinase / Uridine kinase family.
    
  0.700
AEE14069.1
COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR006424:IPR020828:IPR020829; KEGG: saf:SULAZ_0209 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: Strongly similar to glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; IMG reference gene:2504783805; PFAM: Glyceraldehyde 3-phosphate [...]
     
 0.694
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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