STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFV75549.1PFAM: Protein of unknown function (DUF502). (215 aa)    
Predicted Functional Partners:
AFV75546.1
PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
       0.777
AFV75547.1
PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal.
       0.777
AFV75548.1
Hypothetical protein.
       0.777
AFV75550.1
PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain.
       0.769
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.612
AFV75551.1
Hypothetical protein.
       0.590
AFV75552.1
PFAM: CutA1 divalent ion tolerance protein.
       0.590
Your Current Organism:
Thermus oshimai
NCBI taxonomy Id: 751945
Other names: T. oshimai JL-2, Thermus oshimai JL-2, Thermus oshimai str. JL-2, Thermus oshimai strain JL-2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.