node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBL56754.1 | gcvP | PFREUD_12340 | PFREUD_12300 | Forkhead-associated protein; Involved in signal transduction mechanisms. | Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.435 |
CBL56754.1 | odhA | PFREUD_12340 | PFREUD_10250 | Forkhead-associated protein; Involved in signal transduction mechanisms. | 2-oxoglutarate dehydrogenase, E1 and E2 components; Annotated from high similarity with Swiss-Prot entry Q8NRC3, a bifunctional enzyme of Corynebacterium glutamicum with E1 and E2 activity. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.988 |
CBL56754.1 | pdhB | PFREUD_12340 | PFREUD_15940 | Forkhead-associated protein; Involved in signal transduction mechanisms. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine, Glutaryl-CoA + Dihydrolipoamide <=> CoA + S-Glutaryldihydrolipoamide. | 0.480 |
CBL57498.1 | bkdA2 | PFREUD_20050 | PFREUD_02200 | Pyridine nucleotide-disulphide oxidoreductase. | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | 0.893 |
CBL57498.1 | gcvP | PFREUD_20050 | PFREUD_12300 | Pyridine nucleotide-disulphide oxidoreductase. | Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.412 |
CBL57498.1 | odhA | PFREUD_20050 | PFREUD_10250 | Pyridine nucleotide-disulphide oxidoreductase. | 2-oxoglutarate dehydrogenase, E1 and E2 components; Annotated from high similarity with Swiss-Prot entry Q8NRC3, a bifunctional enzyme of Corynebacterium glutamicum with E1 and E2 activity. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.998 |
CBL57498.1 | pdhB | PFREUD_20050 | PFREUD_15940 | Pyridine nucleotide-disulphide oxidoreductase. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine, Glutaryl-CoA + Dihydrolipoamide <=> CoA + S-Glutaryldihydrolipoamide. | 0.853 |
bkdA2 | CBL57498.1 | PFREUD_02200 | PFREUD_20050 | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | Pyridine nucleotide-disulphide oxidoreductase. | 0.893 |
bkdA2 | gcvP | PFREUD_02200 | PFREUD_12300 | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.422 |
bkdA2 | lpd | PFREUD_02200 | PFREUD_10890 | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes. Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine. | 0.993 |
bkdA2 | lpdB | PFREUD_02200 | PFREUD_09310 | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH. | 0.944 |
bkdA2 | merA | PFREUD_02200 | PFREUD_02330 | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | Pyridine nucleotide-disulphide oxidoreductase; Hg + NADP+ + H+ <=> Hg2+ + NADPH. | 0.879 |
bkdA2 | merA-2 | PFREUD_02200 | PFREUD_21320 | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | Pyridine nucleotide-disulphide oxidoreductase; Hg + NADP+ + H+ <=> Hg2+ + NADPH. | 0.879 |
bkdA2 | odhA | PFREUD_02200 | PFREUD_10250 | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | 2-oxoglutarate dehydrogenase, E1 and E2 components; Annotated from high similarity with Swiss-Prot entry Q8NRC3, a bifunctional enzyme of Corynebacterium glutamicum with E1 and E2 activity. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.998 |
bkdA2 | pdhB | PFREUD_02200 | PFREUD_15940 | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine, Glutaryl-CoA + Dihydrolipoamide <=> CoA + S-Glutaryldihydrolipoamide. | 0.987 |
gcvP | CBL56754.1 | PFREUD_12300 | PFREUD_12340 | Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Forkhead-associated protein; Involved in signal transduction mechanisms. | 0.435 |
gcvP | CBL57498.1 | PFREUD_12300 | PFREUD_20050 | Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Pyridine nucleotide-disulphide oxidoreductase. | 0.412 |
gcvP | bkdA2 | PFREUD_12300 | PFREUD_02200 | Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061. | 0.422 |
gcvP | icd | PFREUD_12300 | PFREUD_06870 | Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Putative isocitrate/isopropylmalate dehydrogenase; Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.787 |
gcvP | lpd | PFREUD_12300 | PFREUD_10890 | Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes. Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine. | 0.938 |