STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Q7A_946DNA polymerase III epsilon subunit; PFAM: Exonuclease. (240 aa)    
Predicted Functional Partners:
Q7A_157
DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.966
Q7A_1516
PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III (polc).
    
 0.965
dnaX
DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.963
Q7A_945
Signal-transduction protein; PFAM: Putative nucleotidyltransferase substrate binding domain; CBS domain; Cyclic nucleotide-binding domain; Putative nucleotidyltransferase DUF294.
 
    0.958
HolA
PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
    
 0.935
dnaQ
DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.
  
  
  0.933
Q7A_2223
PFAM: DNA polymerase III chi subunit, HolC.
   
 0.919
HolB
DNA polymerase III delta prime subunit; PFAM: ATPase family associated with various cellular activities (AAA); TIGRFAM: DNA polymerase III, delta' subunit.
   
  0.918
Q7A_657
DNA polymerase III epsilon subunit; PFAM: Exonuclease; GIY-YIG catalytic domain; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.
     
 0.904
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.563
Your Current Organism:
Methylophaga nitratireducenticrescens
NCBI taxonomy Id: 754476
Other names: ATCC BAA-2433, DSM 25689, M. nitratireducenticrescens, Methylophaga nitratireducenticrescens Villeneuve et al. 2013, Methylophaga sp. GP59, Methylophaga sp. JAM1, strain JAM1
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