node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | Hsero_4064 | Hsero_4066 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | Imidazoleglycerol-phosphate dehydratase protein. | 0.998 |
hisA | hisD | Hsero_4064 | Hsero_4069 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | Histidinol dehydrogenase oxidoreductase protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisA | hisE | Hsero_4064 | Hsero_4061 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | phosphoribosyl-ATP pyrophosphatase protein. | 0.998 |
hisA | hisF | Hsero_4064 | Hsero_4063 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | Imidazole glycerol-phosphate synthase protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisA | hisF-2 | Hsero_4064 | Hsero_4204 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | Imidazoleglycerol-phosphate synthase protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.990 |
hisA | hisG | Hsero_4064 | Hsero_4070 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | ATP phosphoribosyltransferase protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.995 |
hisA | hisH | Hsero_4064 | Hsero_4065 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | Glutamine amidotransferase protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisA | hisH-2 | Hsero_4064 | Hsero_4203 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | Glutamine amidotransferase protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.996 |
hisA | hisI | Hsero_4064 | Hsero_4062 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | phosphoribosyl-AMP cyclohydrolase protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | Hsero_4064 | Hsero_2944 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | ATP phosphoribosyltransferase regulatory subunit protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.944 |
hisB | hisA | Hsero_4066 | Hsero_4064 | Imidazoleglycerol-phosphate dehydratase protein. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase protein. | 0.998 |
hisB | hisD | Hsero_4066 | Hsero_4069 | Imidazoleglycerol-phosphate dehydratase protein. | Histidinol dehydrogenase oxidoreductase protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | Hsero_4066 | Hsero_4061 | Imidazoleglycerol-phosphate dehydratase protein. | phosphoribosyl-ATP pyrophosphatase protein. | 0.998 |
hisB | hisF | Hsero_4066 | Hsero_4063 | Imidazoleglycerol-phosphate dehydratase protein. | Imidazole glycerol-phosphate synthase protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisB | hisF-2 | Hsero_4066 | Hsero_4204 | Imidazoleglycerol-phosphate dehydratase protein. | Imidazoleglycerol-phosphate synthase protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.996 |
hisB | hisG | Hsero_4066 | Hsero_4070 | Imidazoleglycerol-phosphate dehydratase protein. | ATP phosphoribosyltransferase protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.998 |
hisB | hisH | Hsero_4066 | Hsero_4065 | Imidazoleglycerol-phosphate dehydratase protein. | Glutamine amidotransferase protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisB | hisH-2 | Hsero_4066 | Hsero_4203 | Imidazoleglycerol-phosphate dehydratase protein. | Glutamine amidotransferase protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.996 |
hisB | hisI | Hsero_4066 | Hsero_4062 | Imidazoleglycerol-phosphate dehydratase protein. | phosphoribosyl-AMP cyclohydrolase protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.997 |
hisB | hisZ | Hsero_4066 | Hsero_2944 | Imidazoleglycerol-phosphate dehydratase protein. | ATP phosphoribosyltransferase regulatory subunit protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.957 |