node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADV10007.1 | ADV11192.1 | Mesci_0840 | Mesci_2039 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.521 |
ADV10007.1 | ADV11531.1 | Mesci_0840 | Mesci_2384 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.970 |
ADV10007.1 | ADV12251.1 | Mesci_0840 | Mesci_3127 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.552 |
ADV10007.1 | ADV12264.1 | Mesci_0840 | Mesci_3140 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | KEGG: mlo:mlr1566 cystathionine gamma-lyase; manually curated; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.923 |
ADV10007.1 | ADV12486.1 | Mesci_0840 | Mesci_3363 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | Methionine synthase; KEGG: mlo:mlr1243 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS. | 0.919 |
ADV10007.1 | ADV12487.1 | Mesci_0840 | Mesci_3364 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mlr1241 hypothetical protein. | 0.521 |
ADV10007.1 | ADV12510.1 | Mesci_0840 | Mesci_3387 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | PFAM: homocysteine S-methyltransferase; KEGG: mlo:mlr1220 methionine synthase I. | 0.933 |
ADV10007.1 | ADV13769.1 | Mesci_0840 | Mesci_4660 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | KEGG: mlo:mll8145 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.922 |
ADV10007.1 | metZ | Mesci_0840 | Mesci_5982 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.832 |
ADV11192.1 | ADV10007.1 | Mesci_2039 | Mesci_0840 | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | 0.521 |
ADV11192.1 | ADV11531.1 | Mesci_2039 | Mesci_2384 | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.991 |
ADV11192.1 | ADV12251.1 | Mesci_2039 | Mesci_3127 | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.911 |
ADV11192.1 | ADV12264.1 | Mesci_2039 | Mesci_3140 | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | KEGG: mlo:mlr1566 cystathionine gamma-lyase; manually curated; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.521 |
ADV11192.1 | ADV12486.1 | Mesci_2039 | Mesci_3363 | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; KEGG: mlo:mlr1243 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS. | 0.969 |
ADV11192.1 | ADV12494.1 | Mesci_2039 | Mesci_3371 | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; KEGG: mlo:mlr1231 corrinoid methyltransferase protein; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein. | 0.471 |
ADV11192.1 | ADV12510.1 | Mesci_2039 | Mesci_3387 | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: homocysteine S-methyltransferase; KEGG: mlo:mlr1220 methionine synthase I. | 0.960 |
ADV11192.1 | ADV13769.1 | Mesci_2039 | Mesci_4660 | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | KEGG: mlo:mll8145 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.521 |
ADV11192.1 | metZ | Mesci_2039 | Mesci_5982 | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.521 |
ADV11531.1 | ADV10007.1 | Mesci_2384 | Mesci_0840 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mlo:mll4503 cystathionine gamma-lyase. | 0.970 |
ADV11531.1 | ADV11192.1 | Mesci_2384 | Mesci_2039 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: sme:SMa2143 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.991 |