STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W4YUZ6_STRPU2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (446 aa)    
Predicted Functional Partners:
W4XZU8_STRPU
Transket_pyr domain-containing protein.
 0.999
W4Z3Z1_STRPU
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
 
 0.999
W4ZJI6_STRPU
SET domain-containing protein.
 
 0.999
W4ZKK7_STRPU
Dihydrolipoyl dehydrogenase.
  
 
 0.998
W4Y9G1_STRPU
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
 
 0.984
W4YJL7_STRPU
Lipoyl-binding domain-containing protein.
 
 0.983
W4YY35_STRPU
Uncharacterized protein.
 
 0.982
W4XIU0_STRPU
FAD_binding_2 domain-containing protein.
  
 
 0.981
W4XAJ5_STRPU
Peripheral subunit-binding (PSBD) domain-containing protein.
  
 0.975
W4Z7I3_STRPU
Citrate synthase; Belongs to the citrate synthase family.
     
 0.973
Your Current Organism:
Strongylocentrotus purpuratus
NCBI taxonomy Id: 7668
Other names: S. purpuratus, purple sea urchin, purple urchin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.