STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W4Z4M1_STRPUCENP-T_C domain-containing protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (379 aa)    
Predicted Functional Partners:
W4XPC8_STRPU
Histone acetyltransferase type B catalytic subunit.
    
 0.811
W4Y269_STRPU
ARID domain-containing protein.
    
 0.722
W4YZA2_STRPU
Tudor domain-containing protein.
    
 0.722
W4XMU0_STRPU
Ubiquitin-like domain-containing protein.
   
 0.695
W4XRL6_STRPU
Uncharacterized protein.
    
 0.690
W4ZK05_STRPU
Uncharacterized protein.
    
 0.673
W4XIM4_STRPU
Uncharacterized protein.
    
 0.671
W4XGX0_STRPU
Uncharacterized protein.
    
  0.665
W4YUG6_STRPU
DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
    
  0.665
W4Z6D7_STRPU
RNA_pol_L_2 domain-containing protein.
    
 0.664
Your Current Organism:
Strongylocentrotus purpuratus
NCBI taxonomy Id: 7668
Other names: S. purpuratus, purple sea urchin, purple urchin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.