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doeB protein (Halomonas elongata) - STRING interaction network
"doeB" - N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase in Halomonas elongata
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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doeBN-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the deacetylation of N-alpha-acetyl-L-2,4- diaminobutyrate (N-alpha-Ac-DABA) to yield L-2,4-diaminobutyrate (DABA) (342 aa)    
Predicted Functional Partners:
doeA
Ectoine hydrolase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4- diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N- gamma-acetyl-L-2,4-diaminobutyric acid (N-gamma-Ac-DABA) and N- alpha-acetyl-L-2,4-diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha- [...] (399 aa)
 
   
  0.998
doeD
Diaminobutyrate--2-oxoglutarate transaminase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the conversion of L-2,4-diaminobutyrate (DABA) to L- aspartate beta-semialdehyde (ASA) by transamination with 2- oxoglutarate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family (469 aa)
 
   
  0.975
ectB
Diaminobutyrate--2-oxoglutarate transaminase; Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate. Seems to use L-glutamate specifically as the amino group donor to ASA, as it is not active with L-alanine, L-glutamine, L-aspartate and L-lysine, and is only poorly active with L-homoserine. In the reverse reaction, gamma- aminobutyric acid (GABA) and L-ornithine can also be used as amino group donors to 2-oxoglutarate, but with a reduced activity compared to that with DABA; Belongs to the class-III [...] (421 aa)
         
  0.905
ectA
L-2,4-diaminobutyric acid acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. Does not acetylate amino acids like GABA, L-ornithine, L-lysine and L-aspartate; Belongs to the acetyltransferase family. EctA subfamily (192 aa)
         
  0.905
doeX
Transcriptional regulatory protein DoeX; Acts as a transcriptional regulator. It binds DNA specifically to a fragment from the doeA promoter region (158 aa)
 
     
  0.880
eutC
annotation not available (314 aa)
 
     
  0.689
doeC
Aspartate-semialdehyde dehydrogenase (Non-phosphorylating); Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the NADPH-dependent oxidation of L-aspartate- semialdehyde to yield L-aspartyl-4-phosphate (Probable) (493 aa)
         
  0.618
HELO_3666
YjiR family protein; Uncharacterized HTH-type transcriptional regulator ydcR - Escherichia coli (strain K12),InterPro- Bacterial regulatory protein GntR family, Specificity unclear (468 aa)
 
          0.603
eutB
annotation not available (332 aa)
 
   
  0.500
ghrA
Glyoxylate/hydroxypyruvate reductase; Erythronate-4-phosphate dehydrogenase - Shewanella baltica (strain OS185),InterPro- D-isomer specific 2-hydroxyacid dehydrogenase NAD binding domain, High confidence in function and specificity (308 aa)
              0.493
Your Current Organism:
Halomonas elongata
NCBI taxonomy Id: 768066
Other names: H. elongata DSM 2581, Halomonas elongata, Halomonas elongata ATCC 33173, Halomonas elongata DSM 2581, Halomonas elongata DSM2581, Halomonas elongata str. DSM 2581, Halomonas elongata strain DSM 2581
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