STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
teaATRAP transporter substrate-binding protein TeaA (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Binds ectoine with high affinity. Affinity for hydroxyectoine is approximately 20-fold lower. (341 aa)    
Predicted Functional Partners:
teaB
TRAP transporter small transmembrane protein TeaB (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Belongs to the TRAP transporter small permease family.
 
  
 0.956
teaD
Regulatory protein TeaD; ATP-binding protein that negatively regulates activity of the tripartite ATP-independent periplasmic (TRAP) ectoine transport system TeaABC. May regulate uptake according to the ATP status of the cell.
 
   
 0.956
teaC
TRAP transporter large transmembrane protein TeaC (substrate ectoine); Part of the tripartite ATP-independent periplasmic (TRAP) transport system TeaABC involved in the uptake of ectoine and hydroxyectoine in response to osmotic upshock. Probably functions as a recovery system for synthesized ectoine that leaks out of the cell. Belongs to the TRAP transporter large permease family.
 
  
 0.944
HELO_3707
TRAP transporter small transmembrane protein (tripartite ATP-independent periplasmic transporter; DctQ component).
  
    0.764
mip
Macrophage infectivity potentiator; Outer membrane protein MIP precursor - Legionella pneumophila (strain Corby),InterPro: DNA repair protein RecN, High confidence in function and specificity.
       0.633
doeA
Ectoine hydrolase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4-diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N-gamma-acetyl-L-2,4- diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2,4- diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-A [...]
  
   
 0.580
pcoA
Copper-resistance protein, CopA family; Copper resistance protein A precursor - Escherichia coli,InterPro: Copper-resistance protein CopA, High confidence in function and specificity.
      
 0.547
ectD
Ectoine hydroxylase; Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2- oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.
      
 0.543
yheS
ABC-type transport system ATP-binding protein; Contains 2 ATP-binding domains.
       0.525
HELO_3283
TRAP transporter (tripartite ATP-independent periplasmic transporter), small transmembrane protein (DctQ component), substrate unknown.
  
    0.481
Your Current Organism:
Halomonas elongata
NCBI taxonomy Id: 768066
Other names: H. elongata DSM 2581, Halomonas elongata ATCC 33173, Halomonas elongata DSM 2581, Halomonas elongata str. DSM 2581, Halomonas elongata strain DSM 2581
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