Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
annotation not available (183 aa)
Predicted Functional Partners:
annotation not available (202 aa)
annotation not available (232 aa)
tRNA(Met) cytidine acetyltransferase TmcA; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (787 aa)
Exosome complex component Rrp41; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3’->5’ exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails (245 aa)
Probable tRNA pseudouridine synthase D; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs (415 aa)
annotation not available (420 aa)
Probable tRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (338 aa)
annotation not available (277 aa)
ORC1-type DNA replication protein; Involved in regulation of DNA replication (385 aa)