node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TTX_1837 | hisA | TTX_1837 | TTX_0785 | Putative L-threonine-O-3-phosphate decarboxylase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | 0.909 |
TTX_1837 | hisB | TTX_1837 | TTX_0784 | Putative L-threonine-O-3-phosphate decarboxylase. | Imidazoleglycerol-phosphate dehydratase. | 0.930 |
TTX_1837 | hisC | TTX_1837 | TTX_0780 | Putative L-threonine-O-3-phosphate decarboxylase. | Histidinol-phosphate aminotransferase. | 0.550 |
TTX_1837 | hisD | TTX_1837 | TTX_0782 | Putative L-threonine-O-3-phosphate decarboxylase. | Histidinol dehydrogenase; Belongs to the histidinol dehydrogenase family. | 0.931 |
TTX_1837 | hisE | TTX_1837 | TTX_0781a | Putative L-threonine-O-3-phosphate decarboxylase. | Phosphoribosyl-ATP pyrophosphohydrolase. | 0.899 |
TTX_1837 | hisF | TTX_1837 | TTX_0783 | Putative L-threonine-O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase, cyclase subunit F; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.922 |
TTX_1837 | hisG | TTX_1837 | TTX_0779 | Putative L-threonine-O-3-phosphate decarboxylase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.931 |
TTX_1837 | hisH | TTX_1837 | TTX_0778 | Putative L-threonine-O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit H; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.926 |
TTX_1837 | hisI1 | TTX_1837 | TTX_0781 | Putative L-threonine-O-3-phosphate decarboxylase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.909 |
TTX_1837 | serB | TTX_1837 | TTX_0682 | Putative L-threonine-O-3-phosphate decarboxylase. | Phosphoserine phosphatase. | 0.757 |
hisA | TTX_1837 | TTX_0785 | TTX_1837 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Putative L-threonine-O-3-phosphate decarboxylase. | 0.909 |
hisA | hisB | TTX_0785 | TTX_0784 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Imidazoleglycerol-phosphate dehydratase. | 0.994 |
hisA | hisC | TTX_0785 | TTX_0780 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Histidinol-phosphate aminotransferase. | 0.944 |
hisA | hisD | TTX_0785 | TTX_0782 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Histidinol dehydrogenase; Belongs to the histidinol dehydrogenase family. | 0.993 |
hisA | hisE | TTX_0785 | TTX_0781a | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Phosphoribosyl-ATP pyrophosphohydrolase. | 0.989 |
hisA | hisF | TTX_0785 | TTX_0783 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, cyclase subunit F; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | TTX_0785 | TTX_0779 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.987 |
hisA | hisH | TTX_0785 | TTX_0778 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit H; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisA | hisI1 | TTX_0785 | TTX_0781 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | serB | TTX_0785 | TTX_0682 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Phosphoserine phosphatase. | 0.845 |