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SMAC_00083 protein (Sordaria macrospora) - STRING interaction network
"SMAC_00083" - DOT1 protein in Sordaria macrospora
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SMAC_00083DOT1 protein; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (529 aa)    
Predicted Functional Partners:
SMAC_07534
Hypothetical protein (1314 aa)
     
  0.913
SMAC_06682
Hypothetical protein (907 aa)
     
  0.898
SMAC_07345
Hypothetical protein (331 aa)
       
  0.831
SMAC_05383
Hypothetical protein (1224 aa)
       
  0.831
SMAC_07979
Hypothetical protein (1136 aa)
     
 
  0.814
SMAC_08815
Hypothetical protein (796 aa)
     
 
  0.814
SMAC_02363
Hypothetical protein (136 aa)
       
  0.747
SMAC_02279
Hypothetical protein (155 aa)
       
  0.747
SMAC_02364
Hypothetical protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (103 aa)
       
  0.660
SMAC_05286
Hypothetical protein (103 aa)
       
  0.660
Your Current Organism:
Sordaria macrospora
NCBI taxonomy Id: 771870
Other names: S. macrospora, S. macrospora k-hell, Sordaria, Sordaria macrospora, Sordaria macrospora k hell, Sordaria macrospora k-hell
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