STRINGSTRING
top3a protein (Ciona intestinalis) - STRING interaction network
"top3a" - DNA topoisomerase in Ciona intestinalis
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
top3aDNA topoisomerase ; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (456 aa)    
Predicted Functional Partners:
ENSCING00000002265
Uncharacterized protein (486 aa)
     
  0.984
ENSCING00000021036
Uncharacterized protein (549 aa)
   
  0.969
Cin.29239
Uncharacterized protein (622 aa)
   
  0.969
ENSCING00000002232
Uncharacterized protein (1194 aa)
   
  0.942
ENSCING00000022501
Uncharacterized protein (229 aa)
     
  0.916
ENSCING00000001864
Uncharacterized protein (431 aa)
     
  0.916
ENSCING00000019579
Uncharacterized protein (328 aa)
   
  0.874
Cin.49685
Uncharacterized protein (265 aa)
   
  0.871
ENSCING00000005608
Uncharacterized protein (356 aa)
 
  0.849
ENSCING00000005560
Uncharacterized protein (983 aa)
   
  0.849
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: C. intestinalis, Ciona intestinalis
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