STRINGSTRING
su(h) protein (Ciona intestinalis) - STRING interaction network
"su(h)" - Suppressor of hairless homolog in Ciona intestinalis
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
su(h)Suppressor of hairless homolog ; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity). Required for the transcriptional expression of Brachyury, suggesting that it participates in notochord differentiation (554 aa)    
Predicted Functional Partners:
n
Notch precursor (2549 aa)
     
  0.997
ENSCING00000008407
Uncharacterized protein (534 aa)
     
  0.931
kat2b
Uncharacterized protein (365 aa)
     
  0.931
kat2a
Uncharacterized protein (709 aa)
     
  0.931
cbp
Uncharacterized protein (1533 aa)
       
  0.927
cir
CIR protein (242 aa)
       
  0.901
ctbp1
Uncharacterized protein (442 aa)
     
  0.874
Cin.52569
Histone deacetylase (404 aa)
     
  0.874
ENSCING00000011541
Uncharacterized protein (839 aa)
     
  0.841
ENSCING00000008816
Importin subunit alpha (519 aa)
     
      0.829
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: C. intestinalis, Ciona intestinalis
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