STRINGSTRING
n protein (Ciona intestinalis) - STRING interaction network
"n" - Notch precursor in Ciona intestinalis
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nNotch precursor (2549 aa)    
Predicted Functional Partners:
su(h)
Suppressor of hairless homolog ; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity). Required for the transcriptional expression of Brachyury, suggesting that it participates in notochord differentiation (554 aa)
     
  0.997
ENSCING00000004186
Uncharacterized protein (475 aa)
     
  0.986
ENSCING00000002361
Uncharacterized protein ; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (432 aa)
     
  0.986
delta
Delta protein ; Putative Notch ligand involved in the mediation of Notch signaling (706 aa)
     
0.984
numb
Numb protein (430 aa)
     
  0.979
ENSCING00000005406
Neuralized-a protein (544 aa)
     
  0.972
jagged
Uncharacterized protein ; Putative Notch ligand involved in the mediation of Notch signaling (1043 aa)
     
0.968
LOC778622
Fringe (381 aa)
     
  0.965
ENSCING00000018603
Uncharacterized protein (568 aa)
     
  0.959
ENSCING00000000295
Uncharacterized protein (670 aa)
       
  0.954
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: C. intestinalis, Ciona intestinalis
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