node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Xaut_0078 | Xaut_4391 | Xaut_0078 | Xaut_4391 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpa:RPA2811 possible mazG. | 0.900 |
Xaut_0078 | coaA | Xaut_0078 | Xaut_2287 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | 0.934 |
Xaut_0078 | coaD | Xaut_0078 | Xaut_3787 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.951 |
Xaut_0078 | panC | Xaut_0078 | Xaut_4542 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.915 |
Xaut_2292 | coaA | Xaut_2292 | Xaut_2287 | KEGG: rpe:RPE_0369 hypothetical protein. | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | 0.698 |
Xaut_2292 | hisA | Xaut_2292 | Xaut_2290 | KEGG: rpe:RPE_0369 hypothetical protein. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bbt:BBta_0145 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-i midazolecarboxamide isomerase. | 0.807 |
Xaut_2292 | hisB | Xaut_2292 | Xaut_2293 | KEGG: rpe:RPE_0369 hypothetical protein. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rpe:RPE_0370 imidazoleglycerol-phosphate dehydratase. | 0.790 |
Xaut_2292 | hisE | Xaut_2292 | Xaut_2288 | KEGG: rpe:RPE_0369 hypothetical protein. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: bbt:BBta_0141 phosphoribosyl-ATP pyrophosphohydrolase. | 0.663 |
Xaut_2292 | hisF | Xaut_2292 | Xaut_2289 | KEGG: rpe:RPE_0369 hypothetical protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.800 |
Xaut_2292 | hisH | Xaut_2292 | Xaut_2291 | KEGG: rpe:RPE_0369 hypothetical protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.807 |
Xaut_4391 | Xaut_0078 | Xaut_4391 | Xaut_0078 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpa:RPA2811 possible mazG. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.900 |
Xaut_4391 | coaA | Xaut_4391 | Xaut_2287 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpa:RPA2811 possible mazG. | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | 0.900 |
coaA | Xaut_0078 | Xaut_2287 | Xaut_0078 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.934 |
coaA | Xaut_2292 | Xaut_2287 | Xaut_2292 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | KEGG: rpe:RPE_0369 hypothetical protein. | 0.698 |
coaA | Xaut_4391 | Xaut_2287 | Xaut_4391 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpa:RPA2811 possible mazG. | 0.900 |
coaA | coaD | Xaut_2287 | Xaut_3787 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.934 |
coaA | hisA | Xaut_2287 | Xaut_2290 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bbt:BBta_0145 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-i midazolecarboxamide isomerase. | 0.630 |
coaA | hisB | Xaut_2287 | Xaut_2293 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rpe:RPE_0370 imidazoleglycerol-phosphate dehydratase. | 0.623 |
coaA | hisE | Xaut_2287 | Xaut_2288 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: bbt:BBta_0141 phosphoribosyl-ATP pyrophosphohydrolase. | 0.756 |
coaA | hisF | Xaut_2287 | Xaut_2289 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.634 |