STRINGSTRING
CHEK2 protein (Latimeria chalumnae) - STRING interaction network
"CHEK2" - Checkpoint kinase 2 in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHEK2Checkpoint kinase 2 (411 aa)    
Predicted Functional Partners:
ENSLACG00000006279
Uncharacterized protein (582 aa)
     
  0.985
ATR
Ataxia telangiectasia and Rad3 related (2654 aa)
     
  0.983
ATM
Ataxia telangiectasia mutated (2375 aa)
     
  0.982
TP53
Tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (401 aa)
     
  0.965
TP53BP1
Tumor protein p53 binding protein 1 (2149 aa)
     
  0.929
CDC25C
Cell division cycle 25 homolog C (S. pombe) (561 aa)
     
  0.923
CHEK1
Checkpoint kinase 1 (475 aa)
   
0.918
CDC7
Cell division cycle 7 homolog (S. cerevisiae) (560 aa)
     
 
  0.898
ASF1A
ASF1 anti-silencing function 1 homolog A (S. cerevisiae) (204 aa)
     
 
  0.836
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (201 aa)
     
 
  0.836
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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