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NOTCH3 protein (Latimeria chalumnae) - STRING interaction network
"NOTCH3" - Uncharacterized protein in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH3Uncharacterized protein; Notch homolog 3 (899 aa)    
Predicted Functional Partners:
MAML3
Mastermind-like 3 (Drosophila) (943 aa)
       
 
  0.916
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region a (487 aa)
     
 
  0.893
MAML2
Mastermind-like 2 (Drosophila) (954 aa)
     
 
  0.885
MPP5
Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); Belongs to the MAGUK family (678 aa)
     
 
  0.798
MAML1
Mastermind-like 1 (Drosophila) (1039 aa)
     
 
  0.784
HEY1
Hes-related family bHLH transcription factor with YRPW motif 1 (304 aa)
     
 
  0.677
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family (458 aa)
     
 
  0.640
MPP7
Membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); Belongs to the MAGUK family (576 aa)
     
 
  0.626
ADAM10
ADAM metallopeptidase domain 10 (679 aa)
     
 
  0.622
HEY2
Hes-related family bHLH transcription factor with YRPW motif 2 (339 aa)
     
 
  0.588
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, Latimeria chalumnae, coelacanth
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