STRINGSTRING
NOTCH3 protein (Latimeria chalumnae) - STRING interaction network
"NOTCH3" - Notch 3 in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH3Notch 3 (899 aa)    
Predicted Functional Partners:
NEURL
Neuralized homolog (Drosophila) (568 aa)
       
  0.946
NEURL1B
Neuralized homolog 1B (Drosophila) (534 aa)
       
  0.946
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region (487 aa)
     
 
  0.925
RBPJL
Recombination signal binding protein for immunoglobulin kappa J region-like (512 aa)
     
 
  0.925
DLL1
Delta-like 1 (Drosophila); Putative Notch ligand involved in the mediation of Notch signaling (723 aa)
     
0.921
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (381 aa)
     
  0.921
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (412 aa)
     
  0.921
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (321 aa)
     
  0.921
PSEN2
Presenilin 2 (Alzheimer disease 4); Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (458 aa)
       
  0.894
PSEN1
Presenilin 1; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (465 aa)
       
  0.894
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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