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MC4R protein (Latimeria chalumnae) - STRING interaction network
"MC4R" - Melanocortin 4 receptor in Latimeria chalumnae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MC4RMelanocortin 4 receptor (329 aa)    
Predicted Functional Partners:
POMC
Proopiomelanocortin (255 aa)
     
  0.770
CRH
Corticotropin releasing hormone (166 aa)
     
 
  0.673
GPR176
G protein-coupled receptor 176 (461 aa)
         
  0.667
GNG2
Guanine nucleotide binding protein (G protein), gamma 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (71 aa)
       
  0.610
CRHR1
Corticotropin releasing hormone receptor 1 (376 aa)
     
  0.591
CRHR2
Corticotropin releasing hormone receptor 2 (270 aa)
     
  0.591
TSHR
Thyroid stimulating hormone receptor; Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5) (689 aa)
     
 
  0.585
DRD5
Dopamine receptor D5 (460 aa)
         
0.580
ADORA2A
Adenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (445 aa)
         
0.569
DRD1
Dopamine receptor D1 (453 aa)
         
0.566
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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