STRINGSTRING
MSH2 protein (Latimeria chalumnae) - STRING interaction network
"MSH2" - Uncharacterized protein in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MSH2Uncharacterized protein (447 aa)    
Predicted Functional Partners:
MSH3
mutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR) (798 aa)
 
0.993
MSH6
mutS homolog 6 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR) (1361 aa)
   
0.991
MLH1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (821 aa)
 
  0.986
RPA1
Replication protein A1, 70kDa (495 aa)
     
  0.970
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (872 aa)
   
  0.970
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (260 aa)
     
  0.968
EXO1
Exonuclease 1 (805 aa)
   
  0.962
FEN1
Flap structure-specific endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminat [...] (317 aa)
   
  0.957
PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae) (1040 aa)
   
  0.950
GEN1
Gen endonuclease homolog 1 (Drosophila) (899 aa)
   
  0.935
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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