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APEX2 protein (Latimeria chalumnae) - STRING interaction network
"APEX2" - APEX nuclease (apurinic/apyrimidinic endonuclease) 2 in Latimeria chalumnae
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APEX2APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (532 aa)    
Predicted Functional Partners:
APTX
Aprataxin (372 aa)
   
 
  0.881
NTHL1
Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family (350 aa)
   
 
  0.852
TDP1
tyrosyl-DNA phosphodiesterase 1 (614 aa)
     
 
  0.838
MUTYH
Uncharacterized protein; mutY homolog (140 aa)
     
 
  0.827
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit; Excision repair cross-complementing rodent repair deficiency, complementation group 4 (919 aa)
     
 
  0.800
NEIL2
Uncharacterized protein; Nei endonuclease VIII-like 2 (E. coli) (383 aa)
   
   
  0.793
PNKP
Polynucleotide kinase 3’-phosphatase (611 aa)
   
 
  0.789
ENSLACG00000006207
Si-ch211-141o9.10 (392 aa)
   
 
  0.782
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (317 aa)
     
 
  0.773
UNG
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (315 aa)
   
 
  0.772
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, Latimeria chalumnae, coelacanth
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