STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTGS2Prostaglandin-endoperoxide synthase 2. (620 aa)    
Predicted Functional Partners:
PTGES
Prostaglandin E synthase.
     
 0.959
PTGES2
Prostaglandin E synthase 2; Belongs to the GST superfamily.
     
 0.941
PTGES3
Prostaglandin E synthase 3.
     
 0.940
PTGS1
Prostaglandin-endoperoxide synthase 1.
  
0.927
PRXL2B
Peroxiredoxin like 2B.
     
 0.923
TBXAS1
Thromboxane A synthase 1; Belongs to the cytochrome P450 family.
   
 
 0.913
LOC102357912
Uncharacterized protein.
     
 0.904
LOC102359406
Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.
     
 0.903
LOC102348127
Cytochrome P450, family 2, subfamily U, polypeptide 1.
   
 
  0.900
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.796
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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