STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
PAFAH1B1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)    
Predicted Functional Partners:
PAFAH1B3
Platelet activating factor acetylhydrolase 1b catalytic subunit 3.
    
 0.996
DCTN2
Dynactin subunit 2.
    
 0.985
NUDC
Nuclear distribution C, dynein complex regulator.
   
 0.976
DCTN1
Dynactin 1a.
    
 0.972
DYNC1H1
Dynein cytoplasmic 1 heavy chain 1.
   
 0.970
DYNLL1
Dynein light chain.
    
 0.968
PAFAH1B2
Platelet activating factor acetylhydrolase 1b catalytic subunit 2.
    
 0.965
NDEL1
NudE neurodevelopment protein 1 like 1.
    
 
 0.941
PLA2G7
Platelet-activating factor acetylhydrolase.
     
 0.924
PAFAH2
Platelet-activating factor acetylhydrolase.
     
 0.924
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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