node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cyp11a1 | cyp17a1 | ENSDARP00000025030 | ENSDARP00000043155 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.964 |
cyp11a1 | cyp19a1a | ENSDARP00000025030 | ENSDARP00000111604 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.580 |
cyp11a1 | esr2a | ENSDARP00000025030 | ENSDARP00000110930 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Estrogen receptor beta2. | 0.755 |
cyp11a1 | fshr | ENSDARP00000025030 | ENSDARP00000096529 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.719 |
cyp11a1 | gper1 | ENSDARP00000025030 | ENSDARP00000156576 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | G-protein coupled estrogen receptor 1; Membrane G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in the embryonic development of sensory and motor neurons. Specifically induces apoptosis and reduces proliferation of brain cells. Involved in maintenance of meiotic arrest in oocytes. | 0.400 |
cyp11a1 | pgr | ENSDARP00000025030 | ENSDARP00000109370 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Progesterone receptor. | 0.613 |
cyp11a1 | star | ENSDARP00000025030 | ENSDARP00000023907 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). | 0.952 |
cyp11a1 | vtg1 | ENSDARP00000025030 | ENSDARP00000050237 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Vitellogenin 1. | 0.451 |
cyp17a1 | cyp11a1 | ENSDARP00000043155 | ENSDARP00000025030 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.964 |
cyp17a1 | cyp19a1a | ENSDARP00000043155 | ENSDARP00000111604 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.960 |
cyp17a1 | esr2a | ENSDARP00000043155 | ENSDARP00000110930 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Estrogen receptor beta2. | 0.725 |
cyp17a1 | fshr | ENSDARP00000043155 | ENSDARP00000096529 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.866 |
cyp17a1 | gper1 | ENSDARP00000043155 | ENSDARP00000156576 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | G-protein coupled estrogen receptor 1; Membrane G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in the embryonic development of sensory and motor neurons. Specifically induces apoptosis and reduces proliferation of brain cells. Involved in maintenance of meiotic arrest in oocytes. | 0.541 |
cyp17a1 | pgr | ENSDARP00000043155 | ENSDARP00000109370 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Progesterone receptor. | 0.606 |
cyp17a1 | star | ENSDARP00000043155 | ENSDARP00000023907 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). | 0.915 |
cyp17a1 | vtg1 | ENSDARP00000043155 | ENSDARP00000050237 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Vitellogenin 1. | 0.620 |
cyp17a1 | vtg2 | ENSDARP00000043155 | ENSDARP00000061164 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Vitellogenin 2. | 0.480 |
cyp19a1a | cyp11a1 | ENSDARP00000111604 | ENSDARP00000025030 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.580 |
cyp19a1a | cyp17a1 | ENSDARP00000111604 | ENSDARP00000043155 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.960 |
cyp19a1a | esr2a | ENSDARP00000111604 | ENSDARP00000110930 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Estrogen receptor beta2. | 0.905 |