node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SPHK1 | acer1 | ENSDARP00000132891 | ENSDARP00000120885 | Sphingosine kinase 1. | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | 0.972 |
SPHK1 | acer2 | ENSDARP00000132891 | ENSDARP00000101048 | Sphingosine kinase 1. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.976 |
SPHK1 | asah1a | ENSDARP00000132891 | ENSDARP00000007893 | Sphingosine kinase 1. | N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. | 0.980 |
SPHK1 | asah1b | ENSDARP00000132891 | ENSDARP00000040433 | Sphingosine kinase 1. | N-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family. | 0.978 |
SPHK1 | asah2 | ENSDARP00000132891 | ENSDARP00000119244 | Sphingosine kinase 1. | Neutral ceramidase; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate fr [...] | 0.985 |
SPHK1 | cerk | ENSDARP00000132891 | ENSDARP00000117613 | Sphingosine kinase 1. | Ceramide kinase. | 0.441 |
SPHK1 | kdsr | ENSDARP00000132891 | ENSDARP00000009670 | Sphingosine kinase 1. | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.946 |
SPHK1 | sgms1 | ENSDARP00000132891 | ENSDARP00000117358 | Sphingosine kinase 1. | Sphingomyelin synthase 1. | 0.405 |
SPHK1 | sphk2 | ENSDARP00000132891 | ENSDARP00000131179 | Sphingosine kinase 1. | Sphingosine kinase 2. | 0.909 |
SPHK1 | zgc:158263 | ENSDARP00000132891 | ENSDARP00000036893 | Sphingosine kinase 1. | Zgc:158263. | 0.444 |
acer1 | SPHK1 | ENSDARP00000120885 | ENSDARP00000132891 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Sphingosine kinase 1. | 0.972 |
acer1 | acer2 | ENSDARP00000120885 | ENSDARP00000101048 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.911 |
acer1 | asah1a | ENSDARP00000120885 | ENSDARP00000007893 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. | 0.989 |
acer1 | asah1b | ENSDARP00000120885 | ENSDARP00000040433 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | N-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family. | 0.990 |
acer1 | asah2 | ENSDARP00000120885 | ENSDARP00000119244 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Neutral ceramidase; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate fr [...] | 0.993 |
acer1 | cerk | ENSDARP00000120885 | ENSDARP00000117613 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Ceramide kinase. | 0.973 |
acer1 | kdsr | ENSDARP00000120885 | ENSDARP00000009670 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.672 |
acer1 | sgms1 | ENSDARP00000120885 | ENSDARP00000117358 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Sphingomyelin synthase 1. | 0.933 |
acer1 | sphk2 | ENSDARP00000120885 | ENSDARP00000131179 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Sphingosine kinase 2. | 0.982 |
acer1 | zgc:158263 | ENSDARP00000120885 | ENSDARP00000036893 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Zgc:158263. | 0.973 |