node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acer1 | acer2 | ENSDARP00000120885 | ENSDARP00000101048 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.911 |
acer1 | asah1a | ENSDARP00000120885 | ENSDARP00000007893 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. | 0.989 |
acer1 | asah1b | ENSDARP00000120885 | ENSDARP00000040433 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | N-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family. | 0.990 |
acer1 | asah2 | ENSDARP00000120885 | ENSDARP00000119244 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Neutral ceramidase; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate fr [...] | 0.993 |
acer1 | cers5 | ENSDARP00000120885 | ENSDARP00000002973 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Ceramide synthase 5. | 0.503 |
acer1 | galca | ENSDARP00000120885 | ENSDARP00000053869 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. | 0.934 |
acer1 | galcb | ENSDARP00000120885 | ENSDARP00000018263 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Galactosylceramidase b. | 0.921 |
acer1 | sgms1 | ENSDARP00000120885 | ENSDARP00000117358 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Sphingomyelin synthase 1. | 0.933 |
acer1 | zgc:158263 | ENSDARP00000120885 | ENSDARP00000036893 | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | Zgc:158263. | 0.973 |
acer2 | acer1 | ENSDARP00000101048 | ENSDARP00000120885 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | 0.911 |
acer2 | asah1a | ENSDARP00000101048 | ENSDARP00000007893 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. | 0.987 |
acer2 | asah1b | ENSDARP00000101048 | ENSDARP00000040433 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | N-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family. | 0.990 |
acer2 | asah2 | ENSDARP00000101048 | ENSDARP00000119244 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Neutral ceramidase; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate fr [...] | 0.995 |
acer2 | cers5 | ENSDARP00000101048 | ENSDARP00000002973 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Ceramide synthase 5. | 0.748 |
acer2 | galca | ENSDARP00000101048 | ENSDARP00000053869 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. | 0.934 |
acer2 | galcb | ENSDARP00000101048 | ENSDARP00000018263 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Galactosylceramidase b. | 0.922 |
acer2 | sgms1 | ENSDARP00000101048 | ENSDARP00000117358 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingomyelin synthase 1. | 0.953 |
acer2 | zgc:158263 | ENSDARP00000101048 | ENSDARP00000036893 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Zgc:158263. | 0.979 |
asah1a | acer1 | ENSDARP00000007893 | ENSDARP00000120885 | N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. | Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. | 0.989 |
asah1a | acer2 | ENSDARP00000007893 | ENSDARP00000101048 | N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.987 |