node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acaca | acox1 | ENSDARP00000077514 | ENSDARP00000049225 | Acetyl-CoA carboxylase alpha. | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 0.729 |
acaca | elovl6 | ENSDARP00000077514 | ENSDARP00000096379 | Acetyl-CoA carboxylase alpha. | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] | 0.576 |
acaca | elovl6l | ENSDARP00000077514 | ENSDARP00000067536 | Acetyl-CoA carboxylase alpha. | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] | 0.564 |
acaca | fads2 | ENSDARP00000077514 | ENSDARP00000022396 | Acetyl-CoA carboxylase alpha. | Fatty acid desaturase 2; Fatty acid desaturase with both Delta(5) and Delta(6) activities. Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n- 6) and alpha-linolenic acid (ALA) (18:3n-3). | 0.422 |
acaca | fasn | ENSDARP00000077514 | ENSDARP00000112100 | Acetyl-CoA carboxylase alpha. | Coiled-coil domain containing 57. | 0.995 |
acaca | hmgcs1 | ENSDARP00000077514 | ENSDARP00000137373 | Acetyl-CoA carboxylase alpha. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.554 |
acaca | scd | ENSDARP00000077514 | ENSDARP00000124185 | Acetyl-CoA carboxylase alpha. | Stearoyl-CoA desaturase (delta-9-desaturase); Belongs to the fatty acid desaturase type 1 family. | 0.763 |
acaca | scdb | ENSDARP00000077514 | ENSDARP00000147880 | Acetyl-CoA carboxylase alpha. | Stearoyl-CoA desaturase b; Belongs to the fatty acid desaturase type 1 family. | 0.522 |
acaca | srebf2 | ENSDARP00000077514 | ENSDARP00000087122 | Acetyl-CoA carboxylase alpha. | Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). | 0.745 |
acox1 | acaca | ENSDARP00000049225 | ENSDARP00000077514 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | Acetyl-CoA carboxylase alpha. | 0.729 |
acox1 | fads2 | ENSDARP00000049225 | ENSDARP00000022396 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | Fatty acid desaturase 2; Fatty acid desaturase with both Delta(5) and Delta(6) activities. Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n- 6) and alpha-linolenic acid (ALA) (18:3n-3). | 0.591 |
acox1 | fasn | ENSDARP00000049225 | ENSDARP00000112100 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | Coiled-coil domain containing 57. | 0.833 |
acox1 | hmgcs1 | ENSDARP00000049225 | ENSDARP00000137373 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.424 |
acox1 | scd | ENSDARP00000049225 | ENSDARP00000124185 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | Stearoyl-CoA desaturase (delta-9-desaturase); Belongs to the fatty acid desaturase type 1 family. | 0.602 |
acox1 | scdb | ENSDARP00000049225 | ENSDARP00000147880 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | Stearoyl-CoA desaturase b; Belongs to the fatty acid desaturase type 1 family. | 0.500 |
acox1 | srebf2 | ENSDARP00000049225 | ENSDARP00000087122 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). | 0.498 |
cyb5r4 | fads2 | ENSDARP00000003991 | ENSDARP00000022396 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Fatty acid desaturase 2; Fatty acid desaturase with both Delta(5) and Delta(6) activities. Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n- 6) and alpha-linolenic acid (ALA) (18:3n-3). | 0.629 |
cyb5r4 | scd | ENSDARP00000003991 | ENSDARP00000124185 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Stearoyl-CoA desaturase (delta-9-desaturase); Belongs to the fatty acid desaturase type 1 family. | 0.786 |
cyb5r4 | scdb | ENSDARP00000003991 | ENSDARP00000147880 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Stearoyl-CoA desaturase b; Belongs to the fatty acid desaturase type 1 family. | 0.715 |
elovl6 | acaca | ENSDARP00000096379 | ENSDARP00000077514 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] | Acetyl-CoA carboxylase alpha. | 0.576 |